Cardiovascular Risk Factors and Age-related Macular Degeneration: The Los Angeles Latino Eye Study
Samantha Fraser-Bell,Joanne Wu,Ronald Klein,Stanley P. Azen,Claire Y. Hooper,Athena W.P. Foong,Rohit Varma +6 more
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TLDR
Cardiovascular risk factors and ocular perfusion pressure with early and advanced age-related macular degeneration in Latinos suggest that in Latinos cardiovascular risk factors may play a role in advanced AMD.Citations
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Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
Usha Chakravarthy,Tien Yin Wong,Tien Yin Wong,Astrid E. Fletcher,Elisabeth Piault,Christopher M. Evans,Gergana Zlateva,Ronald Buggage,Andreas M. Pleil,Paul Mitchell +9 more
TL;DR: Increasing age, current cigarette smoking, previous cataract surgery, and a family history of AMD showed strong and consistent associations with late AMD.
Journal ArticleDOI
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
TL;DR: It is imperative that researchers tease out the various contributions of such factors to AMD development but also the connections between AMD and CVD to develop optimal precision medical care for aging adults.
Journal ArticleDOI
Dietary hyperglycemia, glycemic index and metabolic retinal diseases.
Chung-Jung Chiu,Allen Taylor +1 more
TL;DR: While management of dietary GI appears to be an effective intervention for the prevention of metabolic diseases, specifically AMD and DR, more interventional data is needed to evaluate the efficacy of GI management and an urgent need to develop reliable biomarkers of exposure, surrogate endpoints, as well as susceptibility for GI.
Journal ArticleDOI
Abdominal Obesity and Age-related Macular Degeneration
Madeleine Adams,Julie A. Simpson,Khin Zaw Aung,Galina Makeyeva,Graham G. Giles,Dallas R. English,John L. Hopper,Robyn H. Guymer,Paul N. Baird,Liubov Robman +9 more
TL;DR: In this article, the authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994) and found that each increase of 0.1 in waist/hip ratio was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.11, 2.26; P = 0.02).
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The SECURE study: long-term safety of Ranibizumab 0.5 mg in neovascular age-related macular degeneration
Rufino Silva,Ruth Axer-Siegel,Bora Eldem,Robyn H. Guymer,Bernd Kirchhof,András Papp,Andras Seres,Margarita Gekkieva,Annette Nieweg,Stefan Pilz +9 more
TL;DR: The SECURE study showed that ranibizumab administered as per a VA-guided flexible dosing regimen recommended in the European ranibzumab SmPC at the investigator's discretion was well tolerated over 2 years.
References
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Journal ArticleDOI
Prevalence of age-related macular degeneration in the United States.
David S. Friedman,O'Colmain Bj,Beatriz Munoz,Sandra C. Tomany,Catherine A. McCarty,de Jong Pt,de Jong Pt,de Jong Pt,Barbara Nemesure,Paul Mitchell,Paul Mitchell,John H. Kempen +11 more
TL;DR: In this article, the prevalence and distribution of age-related macular degeneration (AMD) in the United States by age, race/ethnicity, and gender was estimated.
Prevalence of agerelated macular degeneration in the united states
TL;DR: Age-related macular degeneration was far more prevalent among white than among black persons, and the number of persons having AMD will increase by 50% to 2.95 million in 2020.
Journal ArticleDOI
Prevalence of age-related maculopathy. The Beaver Dam Eye Study.
TL;DR: In this article, the relationship between retinal drusen, retinal pigmentary abnormalities, and macular degeneration to age and sex was studied in 4926 people between the ages of 43 and 86 years who participated in the Beaver Dam Eye Study.
Journal ArticleDOI
The Wisconsin age-related maculopathy grading system.
Ronald Klein,Matthew D. Davis,Yvonne L. Magli,Paul Segal,Barbara E.K. Klein,Larry D. Hubbard +5 more
TL;DR: A new system for grading age-related maculopathy using stereoscopic 30 degrees color fundus photographs, standard circles printed on plastic to assess size and area, and a specially designed lightbox to allow better discrimination of subtle drusen is described and measures of reliability are reported.
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Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
TL;DR: There was a significant association between available distribution of C-reactive protein and subsequent coronary heart disease mortality and the association persisted when adjusted for characteristics related to smoking and smoking cessation during the trial and to pulmonary function.
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