Journal ArticleDOI
Cell-cycle checkpoints and cancer
Michael B. Kastan,Jiri Bartek +1 more
Reads0
Chats0
TLDR
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation, and how cells respond to DNA damage are critical determinants of whether that individual will develop cancer.Abstract:
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.read more
Citations
More filters
Journal ArticleDOI
Cell cycle progression in response to oxygen levels.
TL;DR: The role of HIF and the cell molecular oxygen sensors in the control of the cell cycle will be reviewed and HIFs, as well as other components of the hypoxia pathway, can influence cell cycle progression.
Journal ArticleDOI
Importance of DNA damage checkpoints in the pathogenesis of human cancers.
Angela Poehlmann,Albert Roessner +1 more
TL;DR: This review describes in this review both the ATR/ATM-Chk1/Chk2 signaling pathways as well as the regulation of cell cycle checkpoints by MAPK's as molecular mechanisms in DDR and how their dysfunction is related to cancer development.
Journal ArticleDOI
Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis.
Arthur Chiu,Xianglin Shi,W. K. P. Lee,Richard Hill,T. P. Wakeman,A. Katz,Bo Xu,Naresh S. Dalal,J. D. Robertson,C. Chen,N. Chiu,L. Donehower +11 more
TL;DR: Tetravalent chromium may be the most potent species since it causes DNA breaks and somatic recombination, but not apoptosis, and upon further failure of apoptosis and senescence/DNA-repair, damaged cells may become immortal with loss ofheterozygosity and genetic plasticity.
Journal ArticleDOI
BRCAness: Finding the Achilles Heel in Ovarian Cancer
Georgios Rigakos,Evangelia Razis +1 more
TL;DR: A comprehensive review of the relevant literature on the role of BRCAness in ovarian cancer with respect to BRC a function, methods of B RCA epigenetic defect detection and molecular profiling, and the implications of BrcA dysfunction in the treatment of ovarian cancer are presented.
Journal ArticleDOI
Slx4 Regulates DNA Damage Checkpoint-dependent Phosphorylation of the BRCT Domain Protein Rtt107/Esc4
Tania Michelle Roberts,Michael S. Kobor,Michael S. Kobor,Suzanne A. Bastin-Shanower,Miki,Sonja Horte,Jennifer W. Gin,Andrew Emili,Jasper Rine,Steven J. Brill,Grant W. Brown +10 more
TL;DR: It is proposed that Slx4 has roles in the DNA damage response that are distinct from the function of Slx1-Slx4 in maintaining rDNA structure and that Sl x4-dependent phosphorylation of Rtt107 by Mec1 is critical for replication restart after alkylation damage.
References
More filters
Book
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Richard Doll,Richard Peto +1 more
TL;DR: Evidence that the various common types of cancer are largely avoidable diseases is reviewed, and it is suggested that, apart from cancer of the respiratory tract, the types of cancers that are currently common are not peculiarly modern diseases and are likely to depend chiefly on some long-established factor.
Journal ArticleDOI
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
TL;DR: It is shown that ATM is held inactive in unirradiated cells as a dimer or higher-order multimer, with the kinase domain bound to a region surrounding serine 1981 that is contained within the previously described ‘FAT’ domain.
Journal ArticleDOI
Checkpoints: controls that ensure the order of cell cycle events
Leland H. Hartwell,Ted Weinert +1 more
TL;DR: It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.
Journal ArticleDOI
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more
TL;DR: The data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling.
Journal ArticleDOI
ATM and related protein kinases: safeguarding genome integrity
TL;DR: Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.