Journal ArticleDOI
Cellular targets for transformation by the adenovirus E1A proteins
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TLDR
The results suggest that the interactions with these cellular proteins are fundamental to the transforming activity of E1A, including p105-RB, the product of the retinoblastoma susceptibility gene.About:
This article is published in Cell.The article was published on 1989-01-13. It has received 728 citations till now. The article focuses on the topics: Adenovirus early region 1A & Retinoblastoma-Like Protein p107.read more
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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
TL;DR: It is demonstrated that the E6 proteins of the oncogenic HPVs that bind p53 stimulate the degradation of p53, which results in selective degradation of cellular proteins such as p53 with negative regulatory functions provides a novel mechanism of action for dominant-acting oncoproteins.
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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
TL;DR: The results suggest that these three DNA viruses may utilize similar mechanisms in transformation and implicate RB binding as a possible step in human papilloma virus-associated carcinogenesis.
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The regulation of E2F by pRB-family proteins
TL;DR: The rapid growth in the size of the E2F literature hides the fact that several fundamental questions have not been fully answered, and the second section of this review details five unresolved issues that have been highlighted by recent publications.
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G1 events and regulation of cell proliferation.
TL;DR: This work has shown that switches in and out of G1 are the main determinants of post-embryonic cell proliferation rate and are defectively controlled in cancer cells.
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The p53 proto-oncogene can act as a suppressor of transformation
TL;DR: DNA clones of the wild-type p53 proto-oncogene inhibit the ability of E1Aplus ras or mutant p53 plus ras-activated oncogenes to transform primary rat embryo fibroblasts, suggesting that the p53 prototype can act negatively to block transformation.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
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A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels
TL;DR: A simple method for detecting 3H in polyacrylamide gels by scintillation autography (fluorography) using X-ray film, which is ten times more sensitive than conventional autoradiography of isotopes with higher emission energies.
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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.
TL;DR: The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
James A. DeCaprio,John W. Ludlow,James Figge,Jin-Yuh Shew,Chun-Ming Huang,Wen-Hwa Lee,Erika Marsilio,Eva Paucha,David M. Livingston +8 more
TL;DR: Results are consistent with a model for transformation by SV40 which, at least in part, involves T/p110-114 complex formation and the perturbation of Rb protein and/or T function.