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Challenges in the use of zinc and its alloys as biodegradable metals: Perspective from biomechanical compatibility

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TLDR
Common considerations such as strength, ductility, and fatigue behaviors are covered together with special attention on several new uncertainties including low creep resistance, high susceptibility to natural aging, and static recrystallization (SRX) which may lead to device failure during storage at room temperature and clinical usage at body temperature.
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This article is published in Acta Biomaterialia.The article was published on 2019-10-01. It has received 141 citations till now.

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Journal ArticleDOI

Additively manufactured biodegradable porous iron

TL;DR: The first report on topologically ordered porous iron made by Direct Metal Printing (DMP) is presented and it is shown that these implants possess bone-mimicking mechanical properties, accelerated degradation rate, and reasonable cytocompatibility, opening up many new opportunities for the development of biodegradable metallic biomaterials.
Journal ArticleDOI

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives.

TL;DR: Recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs, and the underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties are discussed.
Journal ArticleDOI

Zinc as a Therapeutic Agent in Bone Regeneration

TL;DR: Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration.
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Bioactive glass coatings on metallic implants for biomedical applications.

TL;DR: The present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications.
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Evolution of metallic cardiovascular stent materials: A comparative study among stainless steel, magnesium and zinc.

TL;DR: The results demonstrated that tailored Zn-based material with proper configurations could be a promising candidate for a better stent material in the future.
References
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Journal ArticleDOI

Titanium alloys in total joint replacement—a materials science perspective

TL;DR: This review examines current information on the physical and mechanical characteristics of titanium alloys used in artifical joint replacement prostheses, with a special focus on those issues associated with the long-term prosthetic requirements, e.g., fatigue and wear.
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Metallic implant biomaterials

TL;DR: In this article, the most critical challenges for metallic implant biomaterials are summarized, with emphasis on the most promising approaches and strategies, and the properties that affect biocompatibility and mechanical integrity are discussed in detail.
Journal ArticleDOI

Degradable biomaterials based on magnesium corrosion

TL;DR: Magnesium and its alloys have been investigated recently by many authors as a suitable biodegradable biomaterial as mentioned in this paper, and the latest achievements and comment on the selection and use, test methods and the approaches to develop and produce magnesium alloys that are intended to perform clinically with an appropriate host response.
Journal ArticleDOI

Trace elements in human physiology and pathology: zinc and metallothioneins.

TL;DR: Zinc ions exist primarily in the form of complexes with proteins and nucleic acids and participate in all aspects of intermediary metabolism, transmission and regulation of the expression of genetic information, storage, synthesis and action of peptide hormones and structural maintenance of chromatin and biomembranes.
Book

Texture and Anisotropy: Preferred Orientations in Polycrystals and their Effect on Materials Properties

TL;DR: Mecking et al. as mentioned in this paper described the representation of orientations and textures of textured polycrystals, and showed the elastic inclusion problem can be solved with a texture model.
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