Journal ArticleDOI
Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy.
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TLDR
The identification of predictive biomarkers and an in-depth characterization of molecular circuits governed by Chk1 are issues that need to be addressed for sharpening the therapeutic potential of Chk2 inhibitors.About:
This article is published in Cancer Treatment Reviews.The article was published on 2013-08-01. It has received 52 citations till now. The article focuses on the topics: CHEK1 & Checkpoint Kinase 2.read more
Citations
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Book ChapterDOI
Cell cycle regulation by checkpoints.
TL;DR: Different checkpoint pathways in the cell cycle control alternative cell fates with significant impact on tumor suppression, and the consequences of their dysfunction on cell fate are considered.
Journal ArticleDOI
Roles of Chk1 in cell biology and cancer therapy.
Youwei Zhang,Tony Hunter +1 more
TL;DR: It is suggested that activating, but not inhibiting, Chk1 in the absence of chemotherapy might represent an innovative approach to suppress tumor growth and contribute to anticancer therapy resistance.
Journal ArticleDOI
Replication Catastrophe: When a Checkpoint Fails because of Exhaustion
TL;DR: How such a mechanism can prevent catastrophic genome disruption is discussed and how to harness this knowledge to advance therapeutic strategies to eliminate cancer cells that inherently proliferate under increased DNA replication stress is suggested.
Journal ArticleDOI
CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.
Xuanmao Jiao,Marco A. Velasco-Velázquez,Min Wang,Zhiping Li,Hallgeir Rui,Amy R. Peck,James E. Korkola,Xuelian Chen,Shaohua Xu,James B. DuHadaway,Sandra L. Guerrero-Rodríguez,Sankar Addya,Daniela Sicoli,Zhaomei Mu,Gang Zhang,Andres Stucky,Xi Zhang,Massimo Cristofanilli,Alessandro Fatatis,Joe W. Gray,Jiang F. Zhong,George C. Prendergast,Richard G. Pestell +22 more
TL;DR: This study offers a preclinical rationale to reposition CCR5 inhibitors to improve the treatment of breast cancer, based on their ability to enhance the tumor-specific activities of DNA-damaging chemotherapies administered in that disease.
Journal ArticleDOI
Cancer stem cells: perspectives for therapeutic targeting
TL;DR: Although CSCs still need to be fully characterized, potential candidate markers and/or signaling pathways, to be exploited for the design of novel CSC-targeting therapeutic strategies, are described in this review.
References
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Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.
Journal ArticleDOI
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao,Qiulian Wu,Roger E. McLendon,Yueling Hao,Qing Ming Shi,Anita B. Hjelmeland,Mark W. Dewhirst,Darell D. Bigner,Jeremy N. Rich +8 more
TL;DR: This work shows that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity, and suggests that CD133-positive tumour cells could be the source of tumour recurrence after radiation.
Journal ArticleDOI
DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
TL;DR: In this paper, a histone H2AX species that has been phosphorylated specifically at serine 139 was found to be a major component of DNA double-stranded break.
Journal ArticleDOI
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani,Dario Giuseppe Lombardi,Emanuela Pilozzi,Mauro Biffoni,Matilde Todaro,Cesare Peschle,Ruggero De Maria +6 more
TL;DR: It is concluded that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies.
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