Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy.
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TLDR
This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.Abstract:
With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.read more
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Design components of porphyrin-based photocatalytic hydrogen evolution systems: A review
TL;DR: In this paper , a review of porphyrins and their suitability as photosensitisers and/or proton reduction photocatalysts is discussed, both within homogeneous, heterogeneous and photo-electrochemical environments.
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Probing the Interactions of Porphyrins with Macromolecules Using NMR Spectroscopy Techniques
TL;DR: In this article, a review focusing on non-covalent interactions of porphyrin drugs with synthetic polymers as well as with biomolecules such as phospholipids or proteins is presented.
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BODIPY-vinyl dibromides as triplet sensitisers for photodynamic therapy and triplet-triplet annihilation upconversion.
TL;DR: In this paper, a new generation of halogen-based triplet sensitisers comprising geminal dibromides at the vinyl backbone of a BODIPY fluorophore was devised.
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Understanding Hyperporphyrin Spectra: TDDFT Calculations on Diprotonated Tetrakis(p-aminophenyl)porphyrin.
TL;DR: A detailed TDDFT study with all-electron STO-TZ2P basis sets and the COSMO solvation model was carried out on the effect of diprotonation on the UV-vis-NIR spectra of free-base tetraphenylporphyrin and tetrakis(p-aminophenyl)porphrin this paper.
Enhanced Photodynamic Therapy Effects of Graphene Quantum Dots Conjugated with Aminoporphyrins
Carla I. M. Santos,Carla I. M. Santos,Laura Rodríguez-Pérez,Gil Gonçalves,Cristina J. Dias,Fátima Liliana Monteiro,Maria A. F. Faustino,Sandra Vieira,Luisa A. Helguero,María Herranz,Nazario Martín,M. Graça P. M. S. Neves,José M. G. Martinho,Ermelinda M. S. Maçôas +13 more
TL;DR: Porphyrins are promising materials for photodynamic therapy, but their low solubility and aggregation in biological environments are still obstacles to surpass as discussed by the authors, in order to overcome these limitatio...
References
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TL;DR: The most important factor governing the outcome of PDT is how the PS interacts with cells in the target tissue or tumor, and the key aspect of this interaction is the subcellular localization of the PS.
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The role of porphyrin chemistry in tumor imaging and photodynamic therapy
TL;DR: This critical review is focused on the basic concept of PDT, advantages of long-wavelength absorbing photosensitizers (PS), a brief discussion on recent advances in developing PDT agents, and the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo.