Journal ArticleDOI
Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
Eshvendar Reddy Kasala,Lakshmi Narendra Bodduluru,Chandan C Barua,Rajaram Mohanrao Madhana,Vicky Dahiya,Mukesh Kumar Budhani,Ramana Reddy Mallugari,Suseela Reddy Maramreddy,Ranadeep Gogoi +8 more
Reads0
Chats0
TLDR
Overall, these findings confirm the chemopreventive potential of chrysin against B(a)P induced lung cancer in Swiss albino mice.About:
This article is published in Pharmacological Reports.The article was published on 2016-04-01. It has received 51 citations till now. The article focuses on the topics: Chrysin & Glutathione peroxidase.read more
Citations
More filters
Journal ArticleDOI
Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
Renuka Mani,Vijayakumar Natesan +1 more
TL;DR: This review was mainly focuses on the flavone chrysin (5,7-dihydroxyflavone), which occurs naturally in many plants, honey, and propolis, and exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
Journal ArticleDOI
The differential role of reactive oxygen species in early and late stages of cancer.
TL;DR: Antioxidants should be prohibited in patients with advanced stages of cancer and/or undergoing anticancer therapies, because some polyphenols allow them to selectively recognize tumor cells, and results are encouraging, which may revolutionize the conventional use of antioxidants in cancer.
Journal ArticleDOI
Baicalein Protects Isoproterenol Induced Myocardial Ischemic Injury in Male Wistar Rats by Mitigating Oxidative Stress and Inflammation
TL;DR: In this article, the authors investigated the effect of Baicalein, the main bioactive constituent from the roots of Scutellaria baicalensis, on isoproterenol (ISO) induced acute myocardial infarction model in rats and explored the underlying mechanisms.
Journal ArticleDOI
Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis.
TL;DR: Assessment of protein expression levels by western blot analysis revealed that luteolin treatment effectively negates B(a)P-induced upregulated expression of proliferating cell nuclear antigen (PCNA), cytochrome P450 1A1 (CYP1A1) and nuclear factor-kappa B (NF-κB).
Journal ArticleDOI
Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression.
Lakshmi Narendra Bodduluru,Eshvendar Reddy Kasala,Rajaram Mohanrao Madhana,Chandana Choudhury Barua,Iftikar Hussain,Prakash Haloi,Probodh Borah +6 more
TL;DR: NRG treatment effectively negates B[a]P-induced upregulated expression of CYP1A1, PCNA and NF-κB, showing potent anti-cancer effect in lung cancer.
References
More filters
Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Journal ArticleDOI
Tissue sulfhydryl groups
TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.
Journal ArticleDOI
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.
TL;DR: The results for 20 world regions are presented, summarizing the global patterns for the eight most common cancers, and striking differences in the patterns of cancer from region to region are observed.