Journal ArticleDOI
Circulating miRNA analysis for cancer diagnostics and therapy.
TLDR
This review provides a comprehensive overview of circulating miRNA analysis and highlights the importance of sampling and quality control, the technical aspects of miRNA extraction and quantification, recommendations for downstream analysis and conclude with future perspectives.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2020-04-01. It has received 86 citations till now. The article focuses on the topics: Liquid biopsy & Circulating tumor cell.read more
Citations
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SALMON: Survival Analysis Learning With Multi-Omics Neural Networks on Breast Cancer
Zhi Huang,Xiaohui Zhan,Shunian Xiang,Travis S. Johnson,Travis S. Johnson,Bryan R. Helm,Christina Y. Yu,Christina Y. Yu,Jie Zhang,Paul Salama,Maher Rizkalla,Zhi Han,Zhi Han,Kun Huang,Kun Huang,Kun Huang +15 more
TL;DR: This study implements Deep Learning-based networks to determine how gene expression data predicts Cox regression survival in breast cancer through an algorithm called SALMON (Survival Analysis Learning with Multi-Omics Neural Networks), which aggregates and simplifies gene expressionData and cancer biomarkers to enable prognosis prediction.
Journal ArticleDOI
The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges
TL;DR: In this paper, the authors focused on the factors affecting lung cancer metastasis and connected with related molecular mechanisms of the lung cancer and mechanisms of lung cancer to specific organs, which mainly reviewed the latest research progress of NSCLC metastasis.
Journal ArticleDOI
The miR-200 Family of microRNAs: Fine Tuners of Epithelial-Mesenchymal Transition and Circulating Cancer Biomarkers
Ilaria Cavallari,Francesco Ciccarese,Evgeniya Sharova,Loredana Urso,Vittoria Raimondi,Micol Silic-Benussi,Donna M. D'Agostino,Vincenzo Ciminale +7 more
TL;DR: The miR-200 family of microRNAs (miRNAs) includes miR200a, miR 200b, miRNA-200c, miRN-200a and miR429, five evolutionarily conserved miRNAs that are encoded in two clusters of hairpin precursors located on human chromosome 1 (miR- 200b. as mentioned in this paper ).
Journal ArticleDOI
Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers.
TL;DR: This comprehensive review paper describes recent advances made in the field of electrochemical nanobiosensors for the detection of breast cancer biomarkers such as specific genes, microRNA, proteins, circulating tumor cells, BC cell lines, and exosomes or exosome-derived biomarkers.
Journal ArticleDOI
MicroRNA-Based Diagnosis and Therapy
Phuong Thi Ho,Ian M. Clark,L. Le +2 more
TL;DR: How miRNAs traffic intracellularly and extracellularly is discussed, and how circulating microRNA can be measured is described, emphasizing technical problems that may influence their relative levels.
References
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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
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Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
TL;DR: The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
Journal ArticleDOI
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.
TL;DR: EdgeR as mentioned in this paper is a Bioconductor software package for examining differential expression of replicated count data, which uses an overdispersed Poisson model to account for both biological and technical variability and empirical Bayes methods are used to moderate the degree of overdispersion across transcripts, improving the reliability of inference.
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KEGG: Kyoto Encyclopedia of Genes and Genomes
Minoru Kanehisa,Susumu Goto +1 more
TL;DR: The Kyoto Encyclopedia of Genes and Genomes (KEGG) as discussed by the authors is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules.
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limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
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