Cloning and functional expression of a urea transporter from human bone marrow cells.
Bernadette Olivès,Philippe Neau,Pascal Bailly,M A Hediger,G Rousselet,J.-P. Cartron,Pierre Ripoche +6 more
TLDR
expression studies in Xenopus oocytes demonstrated that HUT11 mediates a facilitated urea transport that was inhibited, as described in mammalian erythrocytes, by very low concentrations of phloretin, p-chloromercuribenzene sulfonate, and urea analogues.About:
This article is published in Journal of Biological Chemistry.The article was published on 1994-12-16 and is currently open access. It has received 191 citations till now. The article focuses on the topics: Urea transport & Urea transporter.read more
Citations
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Pathophysiology of the aquaporin water channels
Landon S. King,Peter Agre +1 more
TL;DR: Specific regulation of membrane water permeability will likely prove important to understanding edema formation and fluid balance in both normal physiology and disease.
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Aquaporin water channels: unanswered questions and unresolved controversies
TL;DR: The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins and Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual Aquaporins.
Journal ArticleDOI
Families of transmembrane transporters selective for amino acids and their derivatives.
TL;DR: Twenty-one families of secondary [proton-motive force (PMF)-driven] carriers are described, which, in addition to 13 of the currently recognized 48 families within the ATP-dependent ATP-binding casette (ABC) superfamily and three families of channel proteins, largely account for the transport of amino acids and their derivatives into and out of all living cells on Earth.
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Urea-selective Concentrating Defect in Transgenic Mice Lacking Urea Transporter UT-B
TL;DR: The ability to concentrate urea in the urine is more severely impaired than the capacity to concentrate other solutes, which defines a novel “urea-selective” urinary concentrating defect in UT-B null mice.
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Urea and urine concentrating ability: new insights from studies in mice.
Baoxue Yang,Lise Bankir +1 more
TL;DR: On the whole, studies in UT-B null mice suggest that recycling of urea by countercurrent exchange in medullary vessels plays a more crucial role in the overall capacity to concentrate urine than its recycling in the loops of Henle.
References
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Genomic sequencing
George M. Church,Walter Gilbert +1 more
TL;DR: The genomic sequencing procedures are applicable to the analysis of genetic polymorphisms, DNA methylation at deoxycytidines, and nucleic acid-protein interactions at single nucleotide resolution.
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The vacuolar membrane protein gamma‐TIP creates water specific channels in Xenopus oocytes.
TL;DR: The results allow us to conclude that the various protein members of the MIP family have unique and specific transport functions and that the plant protein gamma‐TIP likely functions as a water specific channel in the vacuolar membrane.
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Inhibition of water and solute permeability in human red cells.
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Cloning and characterization of the vasopressin-regulated urea transporter
Guofeng You,Craig Smith,Craig Smith,Yoshikatsu Kanai,Yoshikatsu Kanai,Wen Sen Lee,Wen Sen Lee,Matthias Stelzner,Matthias Stelzner,Matthias A. Hediger,Matthias A. Hediger +10 more
TL;DR: In this paper, the authors reported the isolation of a complementary DNA from rabbit renal medulla that encodes a 397amino acid membrane glycoprotein, UT2, with the functional characteristics of the vasopressin-sensitive urea transporter previously described in in vitro-perfused inner medullary collecting ducts.
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Water and urea permeability properties of Xenopus oocytes: expression of mRNA from toad urinary bladder
Rubin Zhang,Alan S. Verkman +1 more
TL;DR: The Xenopus oocyte was evaluated as an mRNA expression system for water and urea transporters and Pf was not altered by removal of the vitelline membrane but was decreased by 75% when the follicular cell layer was intact.