Journal ArticleDOI
Common Inheritance of Susceptibility to Co-Ionic Adenomatous Polyps and Associated Colorectal Cancers
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This article is published in Journal of Occupational and Environmental Medicine.The article was published on 1989-10-01. It has received 77 citations till now.read more
Citations
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Molecular Basis of Colorectal Cancer
TL;DR: This review gives an account of recent advances in the authors' knowledge of the molecular mechanisms in colorectal cancer.
Journal ArticleDOI
Insulin and colon cancer
TL;DR: Hyperinsulinemia may explain why obesity, physical inactivity, and a diet low in fruits and vegetables and high in red meat and extensively processed foods, all common in the West, increase colon cancer risk.
Journal ArticleDOI
Cancer risk in relatives of patients with common colorectal cancer.
D. James B. St. John,Francis T. McDermott,John L. Hopper,Elizabeth A. Debney,William R. Johnson,Edward S. R. Hughes +5 more
TL;DR: A casecontrol family study to assess risk for colorectal cancer in relatives and to define possible markers for any increased risk, using a matched casecontrol design.
Journal Article
Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development: Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia
Joyce O'Shaughnessy,Gary J. Kelloff,Gary Gordon,Andrew J. Dannenberg,Waun Ki Hong,Carol J. Fabian,Caroline C. Sigman,Monica M. Bertagnolli,Steven P. Stratton,Stephen Lam,William G. Nelson,Frank L. Meyskens,David S. Alberts,Michele Follen,Anil K. Rustgi,Vassiliki A. Papadimitrakopoulou,Peter T. Scardino,Adi F. Gazdar,Lee W. Wattenberg,Michael B. Sporn,Wael Sakr,Scott M. Lippman,Daniel D. Von Hoff +22 more
TL;DR: The AACR IEN Task Force recommends focusing on established precancers as the target for new agent development because of the close association between dysplasia and invasive cancer and because a convincing reduction in IEN burden provides patient benefit by reducing cancer risk and/or by decreasing the need for invasive interventions.
References
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Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Molecular Basis of Colorectal Cancer
TL;DR: This review gives an account of recent advances in the authors' knowledge of the molecular mechanisms in colorectal cancer.
Journal ArticleDOI
Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
Stuart Cairns,John H. Scholefield,Robert Steele,Malcolm G. Dunlop,Huw Thomas,Gareth Evans,Jayne Eaden,Matthew D. Rutter,Wendy P Atkin,Brian P. Saunders,Anneke Lucassen,Paul Jenkins,Peter D. Fairclough,Christopher R J Woodhouse,Ireland +14 more
TL;DR: Advice on the appropriateness, method and frequency of screening for people at moderate and high risk from colorectal cancer and for those with inflammatory bowel disease is provided.
Journal ArticleDOI
Insulin and colon cancer
TL;DR: Hyperinsulinemia may explain why obesity, physical inactivity, and a diet low in fruits and vegetables and high in red meat and extensively processed foods, all common in the West, increase colon cancer risk.
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