Molecular Basis of Colorectal Cancer
TLDR
This review gives an account of recent advances in the authors' knowledge of the molecular mechanisms in colorectal cancer.Abstract:
This review gives an account of recent advances in our knowledge of the molecular mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic mutations, occur in familial syndromes of colorectal cancer, whereas somatic mutations are the outstanding feature of sporadic colorectal cancer. Genetic changes drive the progression from adenoma to carcinoma and probably influence individual susceptibility and response to treatment.read more
Citations
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Bevacizumab plus Irinotecan,Fluorouracil,and Leucovorin for Metastatic Colorectal Cancer
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Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors
Fatima Haggar,Robin P. Boushey +1 more
TL;DR: The incidence, mortality, and survival rates for colorectal cancer are reviewed, with attention paid to regional variations and changes over time.
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Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
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Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
NaNa Keum,Edward Giovannucci +1 more
TL;DR: With increasing incidence of CRC at younger ages, there is an urgent need to better identify high-risk individuals younger than 50 years, the age when screening typically starts, and aspirin probably confers chemopreventive benefit against CRC.
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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
Alexandre Calon,Elisa Espinet,Sergio Palomo-Ponce,Daniele V.F. Tauriello,Mar Iglesias,María Virtudes Céspedes,Marta Sevillano,Cristina Nadal,Peter Jung,Xiang Zhang,Daniel Byrom,Antoni Riera,David Rossell,Ramon Mangues,Joan Massagué,Joan Massagué,Elena Sancho,Eduard Batlle +17 more
TL;DR: A prometastatic program induced by TGF-β in the microenvironment that associates with a high risk of CRC relapse upon treatment is unveiled and could be exploited to improve the diagnosis and treatment of CRC.
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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.
David Cunningham,Yves Humblet,Salvatore Siena,David Khayat,Harry Bleiberg,Armando Santoro,D. Bets,M. Mueser,Andreas Harstrick,Chris Verslype,Ian Chau,Eric Van Cutsem +11 more
TL;DR: Cetuximab has clinically significant activity when given alone or in combination with irinotecan in patients with ir inotecans-refractory colorectal cancer.
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