Journal ArticleDOI
Comprehensive molecular characterization of human colon and rectal cancer
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This article is published in Yearbook of Pathology and Laboratory Medicine.The article was published on 2013-01-01. It has received 665 citations till now. The article focuses on the topics: Colorectal cancer.read more
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SWI/SNF Chromatin Remodeling and Human Malignancies
Julien Masliah-Planchon,Ivan Bièche,Jean-Marc Guinebretière,Franck Bourdeaut,Olivier Delattre +4 more
TL;DR: The SWI/SNF complexes, a family of multi-subunit complexes that use the energy of adenosine triphosphate (ATP) hydrolysis to remodel nucleosomes, are a major player in cancer development, progression, and/or resistance to therapy.
Journal ArticleDOI
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Kaja Christine Graue Berg,Kaja Christine Graue Berg,Peter W. Eide,Peter W. Eide,Ina A. Eilertsen,Ina A. Eilertsen,Bjarne Johannessen,Bjarne Johannessen,Jarle Bruun,Jarle Bruun,Stine A. Danielsen,Stine A. Danielsen,Merete Bjørnslett,Merete Bjørnslett,Leonardo A. Meza-Zepeda,Mette Eknæs,Mette Eknæs,Guro Elisabeth Lind,Guro Elisabeth Lind,Ola Myklebost,Ola Myklebost,Rolf Inge Skotheim,Rolf Inge Skotheim,Anita Sveen,Anita Sveen,Ragnhild A. Lothe,Ragnhild A. Lothe +26 more
TL;DR: The view of CRC cell lines as accurate molecular models of primary carcinomas is expanded, and integrated multi-level molecular data of 34 widely used cell lines are presented, providing a resource for preclinical studies in CRC.
Journal ArticleDOI
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study
Emanuele Valtorta,Cosimo Martino,Andrea Sartore-Bianchi,Frédérique Penaullt-Llorca,Giuseppe Viale,Mauro Risio,Massimo Rugge,Walter F. Grigioni,Katia Bencardino,Sara Lonardi,Vittorina Zagonel,Francesco Leone,Johannes Noe,Fortunato Ciardiello,Carmine Pinto,Roberto Labianca,Stefania Mosconi,Claudio Graiff,Giuseppe Aprile,Barbara Frau,Carlo Garufi,Fotios Loupakis,Patrizia Racca,Giuseppe Tonini,Calogero Lauricella,Silvio Veronese,Mauro Truini,Salvatore Siena,Silvia Marsoni,Marcello Gambacorta +29 more
TL;DR: In a phase II trial of trastuzumab and lapatinib in a cetuximab-resistant population, HERACLES Diagnostic Criteria shaped the selection of patients and defined ERBB2 as a predictive marker for response to ER BB2-targeted therapy in metastatic colorectal cancer.
Journal ArticleDOI
Li-Fraumeni syndrome: cancer risk assessment and clinical management
Kate A McBride,Mandy L. Ballinger,Emma Killick,Judy Kirk,Martin H.N. Tattersall,Rosalind A. Eeles,David Thomas,Gillian Mitchell +7 more
TL;DR: The clinical implications of germline mutations in TP53 and the evidence for cancer screening and prevention strategies in individuals carrying such mutations are reviewed, as well as the potential psychosocial implications of lifelong management for a ubiquitous cancer risk.
Journal ArticleDOI
Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma
Ashton A. Connor,Ashton A. Connor,Robert E. Denroche,Robert E. Denroche,Gun Ho Jang,Gun Ho Jang,Gun Ho Jang,Lee Timms,Lee Timms,Sangeetha N Kalimuthu,Iris Selander,Treasa McPherson,Gavin W. Wilson,Michelle Chan-Seng-Yue,Ivan Borozan,Vincent Ferretti,Robert C. Grant,Robert C. Grant,Ilinca Lungu,Eithne Costello,William Greenhalf,Daniel H. Palmer,Paula Ghaneh,John P. Neoptolemos,Markus W. Büchler,Gloria M. Petersen,Sarah P. Thayer,Michael A. Hollingsworth,Alana Sherker,Daniel Durocher,Neesha C. Dhani,David W. Hedley,Stefano Serra,Aaron Pollett,Michael H.A. Roehrl,Michael H.A. Roehrl,Prashant Bavi,John M. S. Bartlett,Sean P. Cleary,Julie M. Wilson,Ludmil B. Alexandrov,Malcolm J. Moore,Bradly G. Wouters,John Douglas Mcpherson,John Douglas Mcpherson,Faiyaz Notta,Lincoln Stein,Lincoln Stein,Steven Gallinger,Steven Gallinger +49 more
TL;DR: Signatures were faithfully propagated from primaries to matched metastases, implying their stability during carcinogenesis, and signature-based subtyping may guide personalized therapy of PDAC in the context of biomarker-driven prospective trials.
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Journal ArticleDOI
Comprehensive molecular characterization of human colon and rectal cancer
Donna M. Muzny,Matthew N. Bainbridge,Kyle Chang,Huyen Dinh,Jennifer Drummond,Gerald R. Fowler,Christie Kovar,Lora Lewis,Margaret Morgan,Irene Newsham,Jeffrey G. Reid,Jireh Santibanez,Eve Shinbrot,Lisa R. Trevino,Yuan Qing Wu,Min Wang,Preethi H. Gunaratne,Preethi H. Gunaratne,Lawrence A. Donehower,Chad J. Creighton,David A. Wheeler,Richard A. Gibbs,Michael S. Lawrence,Douglas Voet,Rui Jing,Kristian Cibulskis,Andrey Sivachenko,Andrey Sivachenko,Petar Stojanov,Aaron McKenna,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Li Ding,Robert S. Fulton,Daniel C. Koboldt,Todd Wylie,Jason Walker,David J. Dooling,Lucinda Fulton,Kim D. Delehaunty,Catrina Fronick,Ryan Demeter,Elaine R. Mardis,Richard K. Wilson,Andy Chu,Hye Jung E. Chun,Andrew J. Mungall,Erin Pleasance,A. Gordon Robertson,Dominik Stoll,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Eric Chuah,Robin J.N. Coope,Noreen Dhalla,Ranabir Guin,Carrie Hirst,Martin Hirst,Robert A. Holt,Darlene Lee,Haiyan I. Li,Michael Mayo,Richard A. Moore,Jacqueline E. Schein,Jared R. Slobodan,Angela Tam,Nina Thiessen,Richard Varhol,Thomas Zeng,Yongjun Zhao,Steven J.M. Jones,Marco A. Marra,Adam J. Bass,Alex H. Ramos,Gordon Saksena,Andrew D. Cherniack,Stephen E. Schumacher,Barbara Tabak,Scott L. Carter,Nam Pho,Huy V. Nguyen,Robert C. Onofrio,Andrew Crenshaw,Kristin G. Ardlie,Rameen Beroukhim,Wendy Winckler,Matthew Meyerson,Alexei Protopopov,Angela Hadjipanayis,Eunjung Lee,Ruibin Xi,Lixing Yang,Xiaojia Ren,Narayanan Sathiamoorthy,Peng Chieh Chen,Psalm Haseley,Yonghong Xiao,Semin Lee,Jonathan G. Seidman,Lynda Chin,Peter J. Park,Raju Kucherlapati,J. Todd Auman,Katherine A. Hoadley,Ying Du,Matthew D. Wilkerson,Yan Shi,Christina Liquori,Shaowu Meng,Ling Li,Yidi J. Turman,Michael D. Topal,Donghui Tan,Scot Waring,Elizabeth Buda,Jesse Walsh,Corbin D. Jones,Piotr A. Mieczkowski,Darshan Singh,Junyuan Wu,Anisha Gulabani,Peter Dolina,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Matthew G. Soloway,Lisle E. Mose,Stuart R. Jefferys,Saianand Balu,Brian O'Connor,Jan F. Prins,Derek Y. Chiang,D. Neil Hayes,Charles M. Perou,Toshinori Hinoue,Daniel J. Weisenberger,Dennis T. Maglinte,Fei Pan,Benjamin P. Berman,David Van Den Berg,Hui Shen,Timothy J. Triche,Stephen B. Baylin,Peter W. Laird,Gad Getz,Michael S. Noble,Doug Voat,Nils Gehlenborg,Daniel DiCara,Juinhua Zhang,Hailei Zhang,Chang-Jiun Wu,Spring Yingchun Liu,Sachet A. Shukla,Lihua Zhou,Pei Lin,Richard W. Park,Marc Danie Nazaire,James A. Robinson,Helga Thorvaldsdottir,Jill P. Mesirov,Vesteinn Thorsson,Sheila Reynolds,Brady Bernard,Richard Kreisberg,Jake Lin,Lisa Iype,Ryan Bressler,Timo Erkkilä,Madhumati Gundapuneni,Yuexin Liu,Adam Norberg,Thomas Robinson,Da Yang,Wei Zhang,Ilya Shmulevich,Jorma J. de Ronde,Jorma J. de Ronde,Nikolaus Schultz,Ethan Cerami,Giovanni Ciriello,Arthur P. Goldberg,Benjamin Gross,Anders Jacobsen,Jianjiong Gao,Bogumil Kaczkowski,Rileen Sinha,B. Arman Aksoy,Yevgeniy Antipin,Boris Reva,Ronglai Shen,Barry S. Taylor,Marc Ladanyi,Chris Sander,Rehan Akbani,Nianxiang Zhang,Bradley M. Broom,Tod D. Casasent,Anna K. Unruh,Chris Wakefield,Stanley R. Hamilton,R. Craig Cason,Keith A. Baggerly,John N. Weinstein,David Haussler,Christopher C. Benz,Joshua M. Stuart,Stephen C. Benz,J. Zachary Sanborn,Charles J. Vaske,Jingchun Zhu,Christopher Szeto,Gary K. Scott,Christina Yau,Sam Ng,Theodore C. Goldstein,Kyle Ellrott,Eric A. Collisson,Aaron E. Cozen,Daniel R. Zerbino,Christopher Wilks,Brian Craft,Paul T. Spellman,Robert Penny,Troy Shelton,Martha Hatfield,Scott Morris,Peggy Yena,Candace Shelton,Mark Sherman,Joseph Paulauskis,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Jay Bowen,Nilsa C. Ramirez,Nilsa C. Ramirez,Aaron D. Black,Robert E. Pyatt,Robert E. Pyatt,Lisa Wise,Peter White,Peter White,Monica M. Bertagnolli,Jen Brown,Timothy A. Chan,Gerald C. Chu,Christine Czerwinski,Fred Denstman,Rajiv Dhir,Arnulf Dörner,Charles S. Fuchs,Jose G. Guillem,Mary Iacocca,Hartmut Juhl,Andrew Kaufman,Bernard Kohl,Xuan Van Le,Maria C. Mariano,Elizabeth N. Medina,Michael Meyers,Garrett M. Nash,P. Paty,Nicholas J. Petrelli,Brenda Rabeno,William G. Richards,David B. Solit,Pat Swanson,Larissa K. Temple,Joel E. Tepper,Richard Thorp,Efsevia Vakiani,Martin R. Weiser,Joseph Willis,Gary Witkin,Zhaoshi Zeng,Michael J. Zinner,Carsten Zornig,Mark A. Jensen,Robert Sfeir,Ari B. Kahn,Anna L. Chu,Prachi Kothiyal,Zhining Wang,Eric E. Snyder,Joan Pontius,Todd Pihl,Brenda Ayala,Mark Backus,Jessica Walton,Jon Whitmore,Julien Baboud,Dominique L. Berton,Matthew C. Nicholls,Deepak Srinivasan,Rohini Raman,Stanley Girshik,Peter A. Kigonya,Shelley Alonso,Rashmi N. Sanbhadti,Sean P. Barletta,John M. Greene,David Pot,Kenna R. Mills Shaw,Laura A.L. Dillon,Kenneth H. Buetow,Tanja Davidsen,John A. Demchok,Greg Eley,Martin L. Ferguson,Peter Fielding,Carl F. Schaefer,Margi Sheth,Liming Yang,Mark S. Guyer,Bradley A. Ozenberger,Jacqueline D. Palchik,Jane Peterson,Heidi J. Sofia,Elizabeth J. Thomson +320 more
TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.