M
Mandy L. Ballinger
Researcher at Garvan Institute of Medical Research
Publications - 106
Citations - 2357
Mandy L. Ballinger is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 24, co-authored 91 publications receiving 1865 citations. Previous affiliations of Mandy L. Ballinger include Baker IDI Heart and Diabetes Institute & The Heart Research Institute.
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Journal ArticleDOI
Li-Fraumeni syndrome: cancer risk assessment and clinical management
Kate A McBride,Mandy L. Ballinger,Emma Killick,Judy Kirk,Martin H.N. Tattersall,Rosalind A. Eeles,David Thomas,Gillian Mitchell +7 more
TL;DR: The clinical implications of germline mutations in TP53 and the evidence for cancer screening and prevention strategies in individuals carrying such mutations are reviewed, as well as the potential psychosocial implications of lifelong management for a ubiquitous cancer risk.
Journal ArticleDOI
Monogenic and polygenic determinants of sarcoma risk: an international genetic study
Mandy L. Ballinger,Mandy L. Ballinger,Mandy L. Ballinger,David L Goode,David L Goode,Isabelle Ray-Coquard,Paul A. James,Paul A. James,Gillian Mitchell,Gillian Mitchell,Eveline Niedermayr,Eveline Niedermayr,Ajay Puri,Joshua D. Schiffman,Gillian S. Dite,Arcadi Cipponi,Robert G. Maki,Andrew S. Brohl,Ola Myklebost,Eva W. Stratford,Susanne Lorenz,Sung-Min Ahn,Jin Hee Ahn,Jeong Eun Kim,Sue Shanley,Sue Shanley,Victoria Beshay,Robert Lor Randall,Ian Judson,Beatrice Seddon,Ian G. Campbell,Ian G. Campbell,Mary-Anne Young,Mary-Anne Young,Rajiv Sarin,Jean-Yves Blay,Seán I. O'Donoghue,Seán I. O'Donoghue,David Thomas +38 more
TL;DR: The genetic basis for bone and soft-tissue sarcoma seen in routine clinical practice is investigated and several classes of pathogenic variants (known, expected, or predicted) were associated with earlier age of cancer onset.
Journal ArticleDOI
Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.
Mandy L. Ballinger,Ana F. Best,Phuong L. Mai,Payal P. Khincha,Jennifer T. Loud,June A. Peters,Maria Isabel Achatz,Rubens Chojniak,Alexandre Balieiro da Costa,Karina Miranda Santiago,Judy Garber,Allison F. O'Neill,Rosalind A. Eeles,D. Gareth Evans,Eveline M. A. Bleiker,Gabe S. Sonke,Marielle W. G. Ruijs,Claudette E. Loo,Joshua D. Schiffman,Anne Naumer,Wendy Kohlmann,Louise C. Strong,Jasmina Bojadzieva,David Malkin,Surya P. Rednam,Elena M. Stoffel,Erika Koeppe,Jeffrey N. Weitzel,Thomas P. Slavin,Bita Nehoray,Mark E. Robson,Michael Walsh,Lorenzo Manelli,Anita Villani,David Thomas,Sharon A. Savage +35 more
TL;DR: Clinical utility of baseline WBMRI in germline TP53 germline mutation carriers at baseline is suggested and may form an integral part of baseline clinical risk management in this high-risk population.
Journal ArticleDOI
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma.
Lisa Mirabello,Bin Zhu,Roelof Koster,Eric Karlins,Michael Dean,Meredith Yeager,Matthew Gianferante,Logan G. Spector,Lindsay M. Morton,Danielle M. Karyadi,Leslie L. Robison,Gregory T. Armstrong,Smita Bhatia,Lei Song,Nathan Pankratz,Maisa Pinheiro,Julie M. Gastier-Foster,Richard Gorlick,Silvia Regina Caminada de Toledo,Antonio Sergio Petrilli,Ana Patiño-García,Fernando Lecanda,Miriam Gutiérrez-Jimeno,Massimo Serra,Claudia Maria Hattinger,Piero Picci,Katia Scotlandi,Adrienne M. Flanagan,Roberto Tirabosco,Maria Fernanda Amary,Nilgun Kurucu,Inci Ergurhan Ilhan,Mandy L. Ballinger,Mandy L. Ballinger,David Thomas,David Thomas,Donald A. Barkauskas,Gerardo Mejia-Baltodano,Patricia Valverde,Belynda Hicks,Mingyi Wang,Amy Hutchinson,Margaret A. Tucker,Joshua N. Sampson,Maria Teresa Landi,Neal D. Freedman,Susan M. Gapstur,Brian D. Carter,Robert N. Hoover,Stephen J. Chanock,Sharon A. Savage +50 more
TL;DR: About one-fourth of patients with osteosarcoma unselected for family history had a highly penetrant germline mutation requiring additional follow-up analysis and possible genetic counseling with cascade testing.
Journal ArticleDOI
Diagnosis of fusion genes using targeted RNA sequencing
Erin E. Heyer,Ira W. Deveson,Ira W. Deveson,Danson Wooi,Danson Wooi,Christina I. Selinger,Ruth J. Lyons,Vanessa M. Hayes,Sandra A O'Toole,Mandy L. Ballinger,Devinder Gill,David Thomas,Tim R. Mercer,Tim R. Mercer,James Blackburn,James Blackburn +15 more
TL;DR: It is demonstrated that targeted RNA sequencing provides fast, sensitive and quantitative gene fusion detection and overcomes the limitations of approaches currently in clinical use.