Journal ArticleDOI
Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury
TLDR
Assessment of the feasibility of using affinity-based delivery systems to release neurotrophin-3 in a controlled manner from fibrin gels as a therapy for spinal cord injury found that heparin concentration modulates diffusion-based release of NT-3.About:
This article is published in Journal of Controlled Release.The article was published on 2004-08-11. It has received 246 citations till now. The article focuses on the topics: Fibrin & Controlled release.read more
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Hydrogels in controlled release formulations: network design and mathematical modeling
Chien-Chi Lin,Andrew T. Metters +1 more
TL;DR: The objective of this article is to review the fundamentals and recent advances in hydrogel network design as well as mathematical modeling approaches related to controlled molecule release from hydrogels.
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Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications
TL;DR: A wide range of natural-origin polymers with special focus on proteins and polysaccharides that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues are overviewed.
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Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
TL;DR: The review includes the novel naturally based hydrogels with high potential for biomedical applications developed in the past five years which integrate the excellent biocompatibility of natural polymers/synthetic polypeptides with structural controllability via chemical modification.
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Fibrin: a versatile scaffold for tissue engineering applications.
TL;DR: Fibrin is a versatile biopolymer, which shows a great potential in tissue regeneration and wound healing, and is summary the latest developments in organ and tissue regeneration using fibrin as the scaffold material.
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From basics to clinical: a comprehensive review on spinal cord injury.
TL;DR: An extensive overview of SCI research, as well as its clinical component, is provided, covering areas from physiology and anatomy of the spinal cord, neuropathology of the SCI, current clinical options, neuronal plasticity after SCI and a variety of promising neuroprotective, cell-based and combinatorial therapeutic approaches that have recently moved, or are close to clinical testing.
References
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Spinal-cord injury
TL;DR: An overview of the newer therapeutic interventions employed in the care of the spinal cord injured individual and the theoretical rationale supporting them is presented.
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Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion.
TL;DR: In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST, and application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres.
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Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury
TL;DR: Grafted NSCs were genetically modified to produce neurotrophin-3, which significantly expanded NSC effects on host axons and confirmed that grafted stem cells expressed neurotrophic factor genes in vivo.
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Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function
TL;DR: Complete spinal cord gaps in adult rats were bridged with multiple intercostal nerve grafts that redirected specific pathways from white to gray matter to suggest a possible repair strategy for spinal cord injury.
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Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury
TL;DR: Findings indicate that several spinal pathways contribute to loss of motor function after spinal cord injury, NT-3 is a neurotrophic factor for the injured corticospinal projection, and functional deficits are partially ameliorated by local cellular delivery ofNT-3.