Journal ArticleDOI
Controlling factors in the synthesis of cucurbituril and its homologues.
Reads0
Chats0
TLDR
A wide range of reaction conditions are examined that include the effects of acid type, acid concentration, reactant concentrations, and temperature to both probe the mechanism and optimize the yields of isolated cucurbit[n]urils, where n = 5-10.Abstract:
The acid-catalyzed synthesis of cucurbit[n]urils from formaldehyde and glycoluril is poorly understood. In this paper, we examine a wide range of reaction conditions that include the effects of acid type, acid concentration, reactant concentrations, and temperature to both probe the mechanism and optimize the yields of isolated cucurbit[n]urils, where n = 5−10. A mechanism for the formation of these cucurbit[n]urils is presented. Individual cucurbit[n]urils were unambiguously identified in reaction mixtures using ESMS and 13C NMR.read more
Citations
More filters
Journal ArticleDOI
Exploration of biocompatible AIEgens from natural resources
Yuan Gu,Zheng Zhao,Huifang Su,Pengfei Zhang,Junkai Liu,Guangle Niu,Shiwu Li,Zhaoyang Wang,Ryan T. K. Kwok,Xin-Long Ni,Jing Zhi Sun,Anjun Qin,Jacky Wing Yip Lam,Ben Zhong Tang +13 more
TL;DR: In this contribution, natural resources are proposed as a new source to acquire biocompatible AIEgens and their applications are proposed.
Journal ArticleDOI
Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment
Nial J. Wheate,Anthony I. Day,Rodney J. Blanch,Alan P. Arnold,Carleen Cullinane,J. Grant Collins +5 more
TL;DR: The dinuclear platinum complex trans-[[Pt(NH(3))(2)Cl](2)micro-dpzm](2+)(di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.
Journal ArticleDOI
Cucurbit[n]urils (n = 5–8): A Comprehensive Solid State Study
David Bardelang,Konstantin A. Udachin,Donald M. Leek,James C. Margeson,Gordon Chan,Christopher I. Ratcliffe,John A. Ripmeester +6 more
TL;DR: In this article, a self-closing effect was rationalized in terms of multiple weak CH···O interactions between the macrocycles, the degree of which is discussed in detail.
Journal ArticleDOI
Encapsulation of Drug Molecules by Cucurbiturils: Effects on their Chemical Properties in Aqueous Solution
TL;DR: The cucurbituril complexation of drug molecules has been shown to generally increase the guests’ pKa values through preferential inclusion of the protonated species, modulate other equilibria involving the guest, improve the solubility in aqueous solution, reduce the toxicity and other side effects, as well as enhance the stability and targeted delivery of the drug molecule.
Journal ArticleDOI
Cucurbit[7]uril containers for targeted delivery of oxaliplatin to cancer cells.
TL;DR: Stay on Target: The cucurbit[7]uril derivative 1 which bears a covalently attached biotin targeting ligand allows for the efficient delivery of oxaliplatin as its 1•oxali Platin complex to cancer cells resulting in enhanced cytotoxicity relative to oxali platin alone.
References
More filters
Journal ArticleDOI
I. Ueber Condensationsproducte aus Glycoluril und Formaldehyd
Journal ArticleDOI
An efficient, enantioselective synthesis of the taxol side chain
TL;DR: Synthese de la chaine du taxol a partir du phenylacetylene avec comme etapes-cle une epoxydation asymetrique et la scission regioselective de l'epoxyde as mentioned in this paper.
Journal ArticleDOI
A Molecular Bowl with Metal Ion as Bottom: Reversible Inclusion of Organic Molecules in Cesium Ion Complexed Cucurbituril
Journal ArticleDOI
Cucurbituril as a ligand for the complexation of cations in aqueous solutions
TL;DR: The complex formation of the ligand cucurbituril with alkaline cations and other cations have been studied by means of solubility measurements in the presence of the salts in aqueous solutions at 25 °C.
Journal ArticleDOI
Host–guest complexes of cucurbituril with the 4-methylbenzylammonium lon, alkali-metal cations and NH4+
TL;DR: In this article, the existence of two different complexes of cucurbituril with 4-methylbenzylammonium ions was reported. But the 1 : 1 stability constants were not reported for the 2 : 1 complexes with different cations.