Journal ArticleDOI
Current and future strategies for treatment of glioma.
TLDR
This review illustrates a multidisciplinary approach to the treatment of glioma and glioblastoma with current advances in surgical approaches, novel imaging techniques, advanced molecular characterization of tumors and translational efforts for treatment.Abstract:
Gliomas are one of the most common types of primary brain tumors and have remained particularly challenging to treat. This review illustrates a multidisciplinary approach to the treatment of glioma and glioblastoma. We will review current advances in surgical approaches, novel imaging techniques, advanced molecular characterization of tumors and translational efforts for treatment. We will focus on current clinical trials as well as the pursuit of personalized or precision therapy. We will also comment on the importance of both quality of life of our patients and their care givers.read more
Citations
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Journal ArticleDOI
Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma.
Spyros Darmanis,Steven A. Sloan,Derek Croote,Marco Mignardi,Sophia B. Chernikova,Peyman Samghababi,Ye Zhang,Norma F. Neff,Mark Kowarsky,Christine Caneda,Gordon Li,Steven D. Chang,Ian D. Connolly,Yingmei Li,Ben A. Barres,Melanie Hayden Gephart,Stephen R. Quake +16 more
TL;DR: Despite the existence of significant heterogeneity among neoplastic cells, it is found that infiltrating GBM cells share a consistent gene signature between patients, suggesting a common mechanism of infiltration.
Proceedings Article
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
TL;DR: Wrensch et al. as mentioned in this paper found that variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility and showed that the direction of association was the same in discovery and replication phases.
Journal ArticleDOI
Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma
TL;DR: An overview on hydrogels loaded with anticancer drugs for the treatment of GBM recently used in preclinical and clinical studies, their advantages and major limitations for clinical translation is provided.
Journal ArticleDOI
Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue
TL;DR: The aim of this review is to recapitulate the pathological features of GBM and of the peritumoral region associated with progression and recurrence and to suggest new immunotherapeutic strategies.
References
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Journal ArticleDOI
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
TL;DR: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
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The 2007 WHO Classification of Tumours of the Central Nervous System
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CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011.
Quinn T. Ostrom,Haley Gittleman,Peter Liao,Chaturia Rouse,Yanwen Chen,Jacqueline Dowling,Yingli Wolinsky,Carol Kruchko,Jill S. Barnholtz-Sloan +8 more
TL;DR: The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the US.
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Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more