Journal ArticleDOI
Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis.
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TLDR
This study provides the first evidence that cyanidin can be used as IL-17/17RA signalling targeting therapeutic drug for the treatment of RA and this need to be investigated in RA patients.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2020-03-15. It has received 18 citations till now. The article focuses on the topics: Cytokine & Cyanidin.read more
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Journal ArticleDOI
lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p.
TL;DR: In this article, siRNA was designed for transfection into fibroblast-like synoviocytes to calculate the lncRNAS56464.1 interference efficiency and then the effect of lncRNA-152-3p/Wnt interference on FLS proliferation was detected by MTT assay.
Journal ArticleDOI
8-Shogaol Inhibits Rheumatoid Arthritis through Targeting TAK1.
Seongin Jo,Snigdha Samarpita,Ji Su Lee,Yong Joon Lee,Joe Eun Son,Minju Jeong,Jae Hwan Kim,S. Hong,Seung-Ah Yoo,Wan-Uk Kim,Mahaboobkhan Rasool,Sang-Hyuk Byun +11 more
TL;DR: Zingiber officinale was found as the top hit and further analysis on the active compound responsible led to the discovery of 8-shogaol as a potent molecule against synovitis as mentioned in this paper .
Journal ArticleDOI
Research Progress of the Role of Anthocyanins on Bone Regeneration
TL;DR: In this paper, the authors summarized the detailed research progress on ACNs on bone regeneration and their molecular mechanisms on promoting osteoblast differentiation as well as inhibiting osteoclast formation and differentiation.
Journal ArticleDOI
Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future?
TL;DR: In this article , a review of various natural compounds/phytochemicals that have proved to be beneficial in attenuating inflammation in RA via modulation of JAK/STAT signaling pathway is presented.
Journal ArticleDOI
Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis.
TL;DR: In this article, a novel therapeutic function of cyanidin towards targeted inhibition of IL-17A/IL-17RA signaling mediated disease severity and bone erosion in RA was proposed.
References
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Journal ArticleDOI
Anti-TNF Antibody Therapy in Rheumatoid Arthritis and the Risk of Serious Infections and Malignancies: Systematic Review and Meta-analysis of Rare Harmful Effects in Randomized Controlled Trials
Tim Bongartz,Alex J. Sutton,Michael J. Sweeting,Iain Buchan,Eric L. Matteson,Victor M. Montori +5 more
TL;DR: There is evidence of an increased risk of serious infections and a dose-dependent increasedrisk of malignancies in patients with rheumatoid arthritis treated with anti-TNF antibody therapy.
Journal ArticleDOI
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Shigeru Kotake,Nobuyuki Udagawa,Naoyuki Takahashi,Kenichiro Matsuzaki,Kanami Itoh,Shigeru Ishiyama,Seiji Saito,Kazuhiko Inoue,Naoyuki Kamatani,Matthew T. Gillespie,T. John Martin,Tatsuo Suda +11 more
TL;DR: It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Journal ArticleDOI
Immunopathogenesis of Rheumatoid Arthritis
TL;DR: Recent data that support intriguing models of disease pathogenesis allude to the possibility of restoration of immunologic homeostasis and thus a state of tolerance associated with drug-free remission of RA, and represents a bold vision for the future of RA therapeutics.
Journal ArticleDOI
Th17 Cell Differentiation: The Long and Winding Road
Mandy J. McGeachy,Daniel J. Cua +1 more
TL;DR: This review aims to bring together the observations that have formed current opinion on factors that promote and contain Th17 cell development, in both mouse and man.
Journal ArticleDOI
Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors
Nunzio Bottini,Gary S. Firestein +1 more
TL;DR: The dual behaviour of FLS in RA suggests that FLS- directed therapies could become a complementary approach to immune-directed therapies in this disease, and progress in targeting these cells is reviewed.
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Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes
Arnaud Hot,Pierre Miossec +1 more