Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
Reads0
Chats0
TLDR
A historic perspective on the development of the field is provided, common trends are emphasized, and new directions in c-di-GMP research are highlighted that will give a deeper understanding of this truly universal bacterial second messenger.Abstract:
SUMMARY Twenty-five years have passed since the discovery of cyclic dimeric (3′→5′) GMP (cyclic di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial cellulose synthase, c-di-GMP has emerged as one of the most common and important bacterial second messengers. Cyclic di-GMP has been shown to regulate biofilm formation, motility, virulence, the cell cycle, differentiation, and other processes. Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells. Cyclic di-GMP plays key roles in lifestyle changes of many bacteria, including transition from the motile to the sessile state, which aids in the establishment of multicellular biofilm communities, and from the virulent state in acute infections to the less virulent but more resilient state characteristic of chronic infectious diseases. From a practical standpoint, modulating c-di-GMP signaling pathways in bacteria could represent a new way of controlling formation and dispersal of biofilms in medical and industrial settings. Cyclic di-GMP participates in interkingdom signaling. It is recognized by mammalian immune systems as a uniquely bacterial molecule and therefore is considered a promising vaccine adjuvant. The purpose of this review is not to overview the whole body of data in the burgeoning field of c-di-GMP-dependent signaling. Instead, we provide a historic perspective on the development of the field, emphasize common trends, and illustrate them with the best available examples. We also identify unresolved questions and highlight new directions in c-di-GMP research that will give us a deeper understanding of this truly universal bacterial second messenger.read more
Citations
More filters
Journal ArticleDOI
The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa
Wee Han Poh,Jianqing Lin,Jianqing Lin,Brendan Colley,Nicolai Müller,Boon Chong Goh,Boon Chong Goh,David Schleheck,Abbas El Sahili,Andreas Marquardt,Yang Liang,Staffan Kjelleberg,Staffan Kjelleberg,Julien Lescar,Scott A. Rice,Scott A. Rice,Janosch Klebensberger +16 more
TL;DR: This study demonstrates that the SiaABC proteins represent a signal response pathway that functions through a partner switch mechanism to control biofilm formation, and identifies promising targets for the development of biofilm-interference drugs to combat infections of this aggressive opportunistic pathogen.
Journal ArticleDOI
Inhibiting effect of quorum quenching on biomass accumulation: A clogging control strategy in gas biofilters
TL;DR: In this paper , the authors developed a new method using enzymatic-quorum quenching (QQ) to simultaneously control biomass and maintain a stable removal efficiency of gas biofilters.
Journal ArticleDOI
Toxin–antitoxin systems and biofilm formation in bacteria
TL;DR: This review focuses on the most recent evidence that connect toxin–antitoxin systems with bacterial biofilm.
Journal ArticleDOI
Tlr0485 is a cAMP-activated c-di-GMP phosphodiesterase in a cyanobacterium Thermosynechococcus.
Gen Enomoto,Gen Enomoto,Ayako Kamiya,Yukiko Okuda,Rei Narikawa,Masahiko Ikeuchi,Masahiko Ikeuchi +6 more
TL;DR: The prevalence of cAMP-activated c-di-GMP phosphodiesterase genes in cyanobacterial genomes suggests that the direct crosstalk between cAMP and c- di-G MP signaling systems may be crucial for cyanob bacterial environmental responses.
Journal ArticleDOI
Functional Characterization of c-di-GMP Signaling-Related Genes in the Probiotic Lactobacillus acidophilus.
TL;DR: The c-di-GMP metabolism-related genes, in L. acidophilus, work jointly to regulate its functions in EPS formation and co-aggregation, implying that the probiotic properties of Lactobacillus species are affected.
References
More filters
Journal ArticleDOI
The Pfam protein families database
Marco Punta,Penny Coggill,Ruth Y. Eberhardt,Jaina Mistry,John Tate,Chris Boursnell,Ningze Pang,Kristoffer Forslund,Goran Ceric,Jody Clements,Andreas Heger,Liisa Holm,Erik L. L. Sonnhammer,Sean R. Eddy,Alex Bateman,Robert D. Finn +15 more
TL;DR: The definition and use of family-specific, manually curated gathering thresholds are explained and some of the features of domains of unknown function (also known as DUFs) are discussed, which constitute a rapidly growing class of families within Pfam.
Journal ArticleDOI
WebLogo: A Sequence Logo Generator
TL;DR: WebLogo generates sequence logos, graphical representations of the patterns within a multiple sequence alignment that provide a richer and more precise description of sequence similarity than consensus sequences and can rapidly reveal significant features of the alignment otherwise difficult to perceive.
Journal ArticleDOI
Pfam: the protein families database.
Robert D. Finn,Alex Bateman,Jody Clements,Penelope Coggill,Ruth Y. Eberhardt,Sean R. Eddy,Andreas Heger,Kirstie Hetherington,Liisa Holm,Jaina Mistry,Erik L. L. Sonnhammer,John Tate,Marco Punta +12 more
TL;DR: Pfam as discussed by the authors is a widely used database of protein families, containing 14 831 manually curated entries in the current version, version 27.0, and has been updated several times since 2012.
Journal ArticleDOI
The COG database: a tool for genome-scale analysis of protein functions and evolution
TL;DR: The database of Clusters of Orthologous Groups of proteins (COGs) is an attempt on a phylogenetic classification of the proteins encoded in 21 complete genomes of bacteria, archaea and eukaryotes.
Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.