Cytochrome P450 2E1 and its roles in disease.
TLDR
The structures, conformations, and catalytic mechanisms of P450 2E1 have some unusual features among P450s, which may have relevance in the rates of oxidation of drugs, particularly acetaminophen and anesthetics.About:
This article is published in Chemico-Biological Interactions.The article was published on 2020-05-01 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Alcohol dehydrogenase & CYP2E1.read more
Citations
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A history of the roles of cytochrome P450 enzymes in the toxicity of drugs.
TL;DR: The maturation of the field of P450 and drug toxicity has been facilitated by advances in analytical chemistry, computational capability, biochemistry and enzymology, and molecular and cell biology.
Journal ArticleDOI
Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?
TL;DR: The current epidemic of obesity and related metabolic diseases has extensively contributed to increase the number of cases of DILI in COVID-19 patients, which may have participated in presentation severity and death.
Journal ArticleDOI
Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges.
Guoqiang Sun,Dawei Rong,Zhouxiao Li,Guangshun Sun,Fan Wu,Xiao Li,Hongyong Cao,Ye Cheng,Weiwei Tang,Yangbai Sun +9 more
TL;DR: In this paper, the authors review the FDA-approved use of small molecule targeted compounds in tumors, summarize the clinical drug resistance problems and mechanisms facing the use of Small-Miner targeted compounds, and predict the future directions of the evolving field.
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Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver
TL;DR: Experimental investigations suggesting that mtCYP2E1 could have a role in alcohol-associated liver disease, xenobiotic-induced hepatotoxicity and NAFLD are discussed.
Journal ArticleDOI
Incidence and risk factors of drug‐induced liver injury
TL;DR: The epidemiology and aetiology of drug‐induced liver injury (DILI) vary across different countries and populations, and traditional Chinese medicine is the primary cause implicated in DILI in the East.
References
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Journal ArticleDOI
Comparison of experimental binding data and theoretical models in proteins containing subunits.
Journal Article
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
TL;DR: The results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis.
Book
Cytochrome P-450: Structure, Mechanism, and Biochemistry
Ortiz de Montellano,R Paul +1 more
TL;DR: The Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids in Plants and the Diversity and Importance of Microbial Cytochromes P450 are studied.
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Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations.
Balaraman Kalyanaraman,Victor M. Darley-Usmar,Kelvin J.A. Davies,Phyllis A. Dennery,Henry Jay Forman,Henry Jay Forman,Matthew B. Grisham,Giovanni E. Mann,Kevin P. Moore,L. Jackson Roberts,Harry Ischiropoulos +10 more
TL;DR: A critical analysis of the challenges and limitations of the most widely used fluorescent probes for detecting and measuring reactive oxygen and nitrogen species and proposed guidelines that will help present and future researchers with regard to the optimal use of selected fluorescent probes and interpretation of results are presented.
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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
TL;DR: The results collectively indicate that P-450 IIE1 is a major catalyst of the oxidation of benzene, styrene, CCl4, CHCl3, CH2Cl2, CH3Cl, 1,2-dichloropropane, ethylene dichloride, vinyl chloride, vinyl bromide, acrylonitrile, vinyl carbamate, ethylcarbamate, and trichloroethylene.