Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma.

TLDR: This guideline recommends the use of a MT/DCR protocol in hospitals that manage such patients and recommends that the protocol target a high ratio of PLAS and PLT to RBC, and conditionally recommend the in-hospital use of TXA early in the management of severely injured bleeding patients.

Abstract: BackgroundThe resuscitation of severely injured bleeding patients has evolved into a multi-modal strategy termed damage control resuscitation (DCR). This guideline evaluates several aspects of DCR including the role of massive transfusion (MT) protocols, the optimal target ratio of plasma (PLAS) and

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SDC TABLE 1: MeSH Terms and Keywords
MeSH Terms
• Antifibrinolytics
• Blood
• Blood transfusion
• Blood transfusion/methods
• Factor VII
• Factor VIIa
• rVIIa
• Fluid therapy/methods
• Fresh Frozen Plasma
• Hemorrhage/surgery
• Hemorrhage/mortality
• Hemorrhage/therapy
• Humans
• Injury Severity Score
• Laparotomy
• Mortality
• Multivariate Analysis
• Packed Red Cells
• Packed Red Blood Cells
• Prospective Studies
• Resuscitation/methods
• Resuscitation/mortality
• Retrospective Studies
• Survival Analysis
• Time Factors
• Tranexamic Acid
• Wounds
• Wounds/mortality
• Wounds/penetrating
• Wounds/surgery
Keywords
• Damage Control Laparotomy
• Damage Control Surgery
• Damage Control Resuscitation
• Ratio