Open Access
Degeneration and regeneration of the nervous system
Santiago Ramón y Cajal
- pp 236-245
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The article was published on 1928-01-01 and is currently open access. It has received 2218 citations till now. The article focuses on the topics: Degeneration (medical) & Regeneration (biology).read more
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Journal ArticleDOI
Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons.
Annalisa Buffo,Marta Zagrebelsky,Andrea Huber,Arne Skerra,Martin E. Schwab,Piergiorgio Strata,Ferdinando Rossi +6 more
TL;DR: Functional neutralization of NI-35/250 proteins induces outgrowth from uninjured Purkinje neurites in the adult cerebellum, which suggests that these molecules regulate axonal plasticity to maintain the proper targeting of terminal arbors within specific gray matter regions.
Journal ArticleDOI
A light and electron microscope study of long-term organized cultures of rat dorsal root ganglia
TL;DR: It is concluded that cultivation of fetal rat dorsal root ganglia by this technique fosters maturation and long-term maintenance of all the elements that comprise this cellular community in vivo and, furthermore, allows these various components to relate faithfully to one another to produce an organotypic model of sensory ganglion tissue.
Journal ArticleDOI
Repair of neural pathways by olfactory ensheathing cells
Geoffrey Raisman,Ying Li +1 more
TL;DR: Transplantation of cultured adult olfactory ensheathing cells into lesions is being investigated as a procedure to re-establish glial pathways permissive for the regeneration of severed axons in the adult CNS.
Journal ArticleDOI
Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases.
Frederique Zindy,Justine J. Cunningham,Charles J. Sherr,Sachin Jogal,Richard J. Smeyne,Martine F. Roussel +5 more
TL;DR: Increased proliferation was balanced by cell death, resulting in no gross changes in the cytoarchitecture of the brains of these mice, suggesting that p19(Ink4d) and p27(Kip1) cooperate to maintain differentiated neurons in a quiescent state that is potentially reversible.
Journal ArticleDOI
Contributions of Pathway and Neuron to Preferential Motor Reinnervation
TL;DR: Stimulation of regenerative collateral sprouting increased preferential motor reinnervation, confirming the pruning hypothesis, but this effect was overshadowed by the dramatic specificity with which predegenerated grafts were reinnervated by fresh uncrushed proximal axons.
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