Journal ArticleDOI
Degradation rate affords a dynamic cue to regulate stem cells beyond varied matrix stiffness.
TLDR
The degradation rate is a dynamic cue influencing cell behaviors, which should be paid attention to for degradable biomaterials.About:
This article is published in Biomaterials.The article was published on 2018-04-12. It has received 113 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
Citations
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Bone physiology as inspiration for tissue regenerative therapies.
TL;DR: A systematic parallelization of fundamental well-established biology of bone, updated and recent advances on the understanding of biological phenomena occurring in native and injured tissue, and critical discussion of how individual aspects have been translated into tissue regeneration strategies using biomaterials and other tissue engineering approaches are suggested.
Journal ArticleDOI
Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications.
TL;DR: This review summarizes the very recent progress of hydrogels used for TE applications and their influences on cell functions and promotive effects on tissue regeneration are highlighted.
Journal ArticleDOI
Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties-From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications.
Evangelia D. Balla,Vasileios Daniilidis,Georgia Karlioti,Theocharis Kalamas,Myrika Stefanidou,Nikolaos D Bikiaris,Antonios Vlachopoulos,Ioanna Koumentakou,Dimitrios N. Bikiaris +8 more
TL;DR: An overview of the current research of lactic acid and lactide dimer techniques along with the production of PLA from its monomers can be found in this paper, where the effect of various catalysts and polymerization conditions is thoroughly presented.
Journal ArticleDOI
Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics.
TL;DR: Dynamic hydrogels as mentioned in this paper can better mimic the dynamics and functions of natural extracellular matrix (ECM) in soft tissues, providing an important means to understand the mechanisms by which cells sense and remodel their surrounding microenvironments.
Journal ArticleDOI
Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate
Alberto Pardo,Manuel Gómez-Florit,Silvia Barbosa,Pablo Taboada,Rui M. A. Domingues,Manuela E. Gomes +5 more
TL;DR: A detailed summary of the main strategies to prepare magnetic nanoparticles showing controlled properties with an analysis of the different approaches available to their incorporation into hydrogels is presented in this paper.
References
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Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Journal ArticleDOI
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Journal ArticleDOI
New perspectives in cell adhesion : RGD and integrins
TL;DR: Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
Journal ArticleDOI
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
TL;DR: Although modern synthetic biomaterials represent oversimplified mimics of natural ECMs lacking the essential natural temporal and spatial complexity, a growing symbiosis of materials engineering and cell biology may ultimately result in synthetic materials that contain the necessary signals to recapitulate developmental processes in tissue- and organ-specific differentiation and morphogenesis.
Journal ArticleDOI
Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment
TL;DR: It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.
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Matrix elasticity directs stem cell lineage specification.
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Ovijit Chaudhuri,Ovijit Chaudhuri,Ovijit Chaudhuri,Luo Gu,Luo Gu,Darinka D. Klumpers,Darinka D. Klumpers,Darinka D. Klumpers,Max Darnell,Max Darnell,Sidi A. Bencherif,Sidi A. Bencherif,James C. Weaver,Nathaniel Huebsch,Hong-pyo Lee,Evi Lippens,Evi Lippens,Georg N. Duda,David J. Mooney,David J. Mooney +19 more