Journal ArticleDOI
Delivery of Growth Factors for Tissue Regeneration and Wound Healing
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TLDR
The role of growth factors in tissue regeneration, and their application in both pre-clinical animal models of regeneration and clinical trials is discussed, and current status of biomaterial substrates and sophisticated delivery systems such as nanoparticles for delivery of exogenous growth factors and peptides in humans are reviewed.Abstract:
Growth factors are soluble secreted proteins capable of affecting a variety of cellular processes important for tissue regeneration. Consequently, the self-healing capacity of patients can be augmented by artificially enhancing one or more processes important for healing through the application of growth factors. However, their application in clinics remains limited due to lack of robust delivery systems and biomaterial carriers. Interestingly, all clinically approved therapies involving growth factors utilize some sort of a biomaterial carrier for growth factor delivery. This suggests that biomaterial delivery systems are extremely important for successful usage of growth factors in regenerative medicine. This review outlines the role of growth factors in tissue regeneration, and their application in both pre-clinical animal models of regeneration and clinical trials is discussed. Additionally, current status of biomaterial substrates and sophisticated delivery systems such as nanoparticles for delivery of exogenous growth factors and peptides in humans are reviewed. Finally, issues and possible future research directions for growth factor therapy in regenerative medicine are discussed.read more
Citations
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Nanoparticles and nanofibers for topical drug delivery.
TL;DR: This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery and provides significant evidence that this area of research has - and will continue to have - a profound impact on both clinical outcomes and the development of new products.
Journal ArticleDOI
Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine
Kevin Dzobo,Kevin Dzobo,Nicholas Ekow Thomford,Dimakatso Alice Senthebane,Dimakatso Alice Senthebane,Hendrina Shipanga,Hendrina Shipanga,Arielle Rowe,Collet Dandara,Michael Pillay,Keolebogile Shirley Motaung +10 more
TL;DR: Several challenges must be overcome in the application of 3D bioprinting before this disruptive technology is widely used to create organotypic constructs for regenerative medicine.
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Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration
TL;DR: The roles of growth factors in wound healing, their clinical applications for the treatment of chronic wounds, and advances in growth factor-loaded DDSs for enhanced wound healing are described, focusing on micro- and nano-particulate systems, scaffolds, hydrogels, and other miscellaneous systems.
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Droplet-born air blowing: Novel dissolving microneedle fabrication
TL;DR: The droplet-born air blowing (DAB) method, which provides gentle (4-25 °C) and fast (≤10min) microneedle fabrication conditions without drug loss, is suggested, which is suitable to design dissolvingmicroneedles for use in biological drug delivery to patients.
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Alginate hydrogel dressings for advanced wound management.
Miao Zhang,Xia Zhao +1 more
TL;DR: In this review, the recent approaches in the chemical and physical preparation and the application of alginate hydrogels in wound dressings are summarized.
References
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Journal ArticleDOI
Polymeric system for dual growth factor delivery
TL;DR: This is the first report of a vehicle capable of delivery of multiple angiogenic factors with distinct kinetics, and these results clearly indicate the importance of multiple growth factor action in tissue regeneration and engineering.
Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
Journal ArticleDOI
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
TL;DR: A review of growth factor delivery in tissue engineering provides an overview of fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives.