Development and Evaluation of Polyvinyl Alcohol-Hydrogels as an Artificial Atrticular Cartilage for Orthopedic Implants
Reads0
Chats0
TLDR
This review will present the overview of the applications and recent advances of PVA-H cartilages, and discuss clinical potential of Pva-H for orthopedics implant.Abstract:
Due to its excellent biocompatibility and mechanical properties, various different applications of polyvinyl alcohol-hydrogels (PVA-H) has been attempted in many fields. In the field of orthopedic surgery, we have been engaged for long time in research on the clinical applications of PVA-H as a artificial cartilage, and have performed many basic experiments on the mechanical properties, synthesis of PVA-H, and developed orthopedic implants using PVA-H. From these studies, many applications of artificial articular cartilage, intervertbral disc and artificial meniscus etc. have been developed. This review will present the overview of the applications and recent advances of PVA-H cartilages, and discuss clinical potential of PVA-H for orthopedics implant.read more
Citations
More filters
Journal ArticleDOI
Composite hydrogels based on gelatin, chitosan and polyvinyl alcohol to biomedical applications: a review
Rogelio Rodríguez-Rodríguez,Hugo Espinosa-Andrews,Cristina Velasquillo-Martínez,Zaira Y. García-Carvajal +3 more
TL;DR: In this article, binary and ternary blends of chitosan, gelatin, and polyvinyl alcohol can lead to hydrogels that are unsuitable for biomedical applications.
Journal ArticleDOI
Evaluation of hydrophobic polyvinyl-alcohol formaldehyde sponges as absorbents for oil spill.
TL;DR: Novel macroporous and hydrophobic polyvinyl formaldehyde (PVF-H) sponges were prepared by the reaction of stearoyl chloride with hydroxyl groups of hydrophilic PVF sponge at different temperatures and had excellent absorption performance on oil products.
Journal ArticleDOI
Evolution of PVA gels prepared without crosslinking agents as a cell adhesive surface
TL;DR: This study demonstrated that transparent pure Poly (vinyl alcohol) hydrogels prepared via a freeze-thaw method can be made to support cell adhesion by controlling physical parameters such as concentration and the number of freeze–thaw cycles.
Journal ArticleDOI
Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds
TL;DR: A simple metric is proposed to enable comparisons between materials and improves the mechanical properties of the hydrogel, while the biocompatibility and functionality of the gels are maintained or even improved.
Journal ArticleDOI
What’s next? Alternative materials for articulation in total joint replacement
TL;DR: This review gives a brief overview of new ceramics and modifications of a bulk metal currently available for total joint replacements or have been used for pre-clinical testing and evaluates the potential of those that have recently been published in literature.
References
More filters
Journal ArticleDOI
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.
TL;DR: For thirty-two areas of cartilage from nine osteo-arthritic and four "normal" femoral heads a histologic-histochemical grade was assigned as an index of severity of the osteo -arthritic process.
Journal ArticleDOI
Activation of Integrin Function by Nanopatterned Adhesive Interfaces
Marco Arnold,Elisabetta Ada Cavalcanti-Adam,Roman Glass,Jacques Blümmel,Wolfgang Eck,Martin Kantlehner,Horst Kessler,Joachim P. Spatz +7 more
TL;DR: It is proposed that the range between 58-73 nm is a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells.
Journal ArticleDOI
Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips
Henry J. Mankin,Louis Lippiello +1 more
TL;DR: Articular cartilage of the proximal end of the femur from patients with osteo-arthritis and "normal" controls with fractures of neck of femur was obtained at the time of surgical replacement of the Femoral head.
Journal ArticleDOI
A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus.
TL;DR: In the results, the articular cartilage state of knee joint implanted PVA-H meniscus was good even after 2 years, while Osteoarthrosis change progressed in meniscectomy knee joint, which proved that an artificial meniscUS using Pva-H can compensate for meniscal function and might be clinically applicable.
Journal ArticleDOI
Using Mixed Self-Assembled Monolayers Presenting RGD and (EG)3OH Groups To Characterize Long-Term Attachment of Bovine Capillary Endothelial Cells to Surfaces
Carmichael Roberts,Christopher S. Chen,Milan Mrksich,Valerie Martichonok,Donald E. Ingber,George M. Whitesides +5 more
TL;DR: Surfaces that promote the ligand-directed binding of cells and resist the cellular deposition of adhesive proteins are described, based on self-assembled monolayers of alkanethiolates on gold that present mixtures of arginine-glycine-aspartate, a tripeptide that promotes cell adhesion by binding to cell surface integrin receptors.