Book ChapterDOI
Development of Retinal Prosthesis Module for Fully Implantable Retinal Prosthesis
Kang-Wook Lee,Tetsu Tanaka +1 more
- Vol. 31, Iss: 4, pp 1625-1628
TLDR
The waveforms of electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module for the first time are recorded.Abstract:
To restore visual sensation of blind patients, we have proposed a fully implantable retinal prosthesis comprising an three dimensionally (3D) stacked retinal chip for transforming optical signal to electrical signal, a flexible cable with stimulus electrode array for stimulating retina cells, and coupling coils for power transmission. For realizing the fully implantable retinal prosthesis, we developed a key component of retinal prosthesis module comprising a retinal prosthesis chip and a flexible cable with stimulus electrode array. In this study, we used a 2D retinal chip as a prototype retinal prosthesis chip. We fabricated a polyimide-based flexible cable of 20μm thickness with 16 channels Pt stimulus electrode array. The retinal prosthesis chip was mounted on the flexible cable and encapsulated by a silicone to protect from corrosive environments in an eyeball. Then, the retinal prosthesis module was completely implanted into an eyeball of a rabbit. We successfully recorded the waveforms of electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module for the first time. EEP amplitudes were proportionally increased according to illumination intensity and irradiation time of the incident light. It means that the rabbit would recognize the change of optical signal by changing the frequency of stimulus current pulse through the implanted retinal chip.read more
Citations
More filters
Journal ArticleDOI
Flexible Charge Balanced Stimulator With 5.6 fC Accuracy for 140 nC Injections
TL;DR: A novel architecture of general purpose biphasic constant current stimulator that exhibits less than 5.6 fC error while injecting 140 nC charges using 1.4 mA currents is presented.
Journal ArticleDOI
A 0.8-V 4096-Pixel CMOS Sense-and-Stimulus Imager for Retinal Prosthesis
Chih-Lin Lee,Chih-Cheng Hsieh +1 more
TL;DR: In this article, an integrated sense-and-stimulus (SAS) function for retinal prosthesis has been implemented for various purposes, such as test mode, programming (PG) mode, and implanted (IP) mode.
References
More filters
Journal ArticleDOI
Pattern electrical stimulation of the human retina
Mark S. Humayun,Eugene de Juan,James D. Weiland,Gislin Dagnelie,Steve Katona,Robert J. Greenberg,Satoshi Suzuki +6 more
TL;DR: Experiments were conducted to study if electrical stimulation of the retinal surface can elicit visual sensation in individuals blind from end-stage retinitis pigmentosa (RP) or age-related macular degeneration (AMD).
Proceedings ArticleDOI
Neuromorphic vision chip fabricated using three-dimensional integration technology
Mitsumasa Koyanagi,Yoshihiro Nakagawa,K. W. Lee,T. Nakamura,Y. Yamada,K. Inamura,Ki-Tae Park,Hiroyuki Kurino +7 more
TL;DR: In this paper, a 3D integration technology for image processing and pattern recognition with parts of functions of the retina and visual cortex using silicon is presented. And the three-dimensional (3D) integration technology achieved an image processing, pattern recognition, and pattern classification system using parts of functional units of the human brain using silicon.