Journal ArticleDOI
Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms.
TLDR
An overview of the recent advances in the study of S-SEDDS, especially the related solidification techniques and the development of solid SE dosage forms is given.About:
This article is published in Drug Discovery Today.The article was published on 2008-07-01. It has received 358 citations till now. The article focuses on the topics: Drug delivery.read more
Citations
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Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
Prakash Khadka,Jieun Ro,Hyeongmin Kim,Iksoo Kim,Jeong Tae Kim,Hyun-Il Kim,Jae Min Cho,Gyiae Yun,Jaehwi Lee +8 more
TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.
Journal ArticleDOI
Oral delivery of anticancer drugs: Challenges and opportunities
TL;DR: Various emerging trends to tackle the challenges associated with oral delivery of anticancer drugs are reviewed, which invariably include efflux transporter based-, functional excipient- and nanocarrier based-approaches.
Journal ArticleDOI
Lyotropic liquid crystal systems in drug delivery
TL;DR: An overview of recent advances and current status of reversed cubic and hexagonal mesophases, especially with respect to their preparation methods and applications in the field of drug delivery is given.
Journal ArticleDOI
Lipid-based formulations for oral administration of poorly water-soluble drugs.
TL;DR: The aim of this review is to provide an overview of the different lipid-based dosage forms from a biopharmaceutical point of view and to describe effects of lipid dosage forms and lipid excipients on drug solubility, absorption and distribution.
References
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Journal ArticleDOI
Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
TL;DR: Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
Journal ArticleDOI
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more
TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.
Journal ArticleDOI
Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects
TL;DR: This review highlights the state-of-the-art in pharmaceutical microemulsions with emphasis on self-emulsifying systems, from both a physical and biopharmaceutical perspective, primarily focused on their potential for oral drug delivery and intestinal absorption improvement.
Journal ArticleDOI
Oral lipid-based formulations
TL;DR: This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives.
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Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more