Diagnosis and Classification of Diabetes Mellitus
TLDR
The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.About:
This article is published in Diabetes Care.The article was published on 2011-02-06 and is currently open access. It has received 13077 citations till now. The article focuses on the topics: Prediabetes & Impaired fasting glucose.read more
Citations
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Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
Luís Rato,Ana I. Duarte,Gonçalo D. Tomás,Maria S. Santos,Paula I. Moreira,Sílvia Socorro,José E. Cavaco,Marco G. Alves,Pedro Oliveira +8 more
TL;DR: Pre-diabetes compromises testicular mitochondrial function by repressing PGC-1α/Sirt3 axis and mtDNA copy number, declining respiratory capacity and increasing oxidative stress, which gives new insights into overall testicular bioenergetics at this prodromal stage of disease.
Journal ArticleDOI
D-mannose induces regulatory T cells and suppresses immunopathology
Dunfang Zhang,Cheryl Chia,Xue Jiao,Xue Jiao,Wenwen Jin,Shimpei Kasagi,Ruiqing Wu,Ruiqing Wu,Joanne E. Konkel,Hiroko Nakatsukasa,Peter Zanvit,Nathan Goldberg,Qianming Chen,Lingyun Sun,Zi-Jiang Chen,Wanjun Chen +15 more
TL;DR: It is shown that supraphysiological levels of D-mannose safely achievable by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation, and increased the proportion of Foxp3+ regulatory T cells (Treg cells) in mice.
Journal ArticleDOI
Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity
Suziy de M. Bandeira,Glaucevane da Silva Guedes,Lucas José Sá da Fonseca,André Simões Pires,Daniel Pens Gelain,José Cláudio Fonseca Moreira,Luiza A. Rabelo,Sandra Mary Lima Vasconcelos,Marília O. F. Goulart +8 more
TL;DR: Present data strongly suggest the involvement of oxidative stress in the pathophysiology of diabetes, revealing that the increased lipid peroxidation has a close relationship with high glucose levels, as observed by the fasting glucose and HbA1c levels.
Journal ArticleDOI
Association of Urinary Metal Profiles with Altered Glucose Levels and Diabetes Risk: A Population-Based Study in China
Wei Feng,Xiuqing Cui,Bing Liu,Chuanyao Liu,Yang Xiao,Wei Lu,Huan Guo,Meian He,Xiaomin Zhang,Jing Yuan,Weihong Chen,Tangchun Wu +11 more
TL;DR: The results suggest that multiple metals in urine are associated with FPG, IFG or diabetes risk, and further prospective studies are warranted to validate the findings.
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Chronic Kidney Disease Awareness Among Individuals with Clinical Markers of Kidney Dysfunction
Delphine S. Tuot,Laura C. Plantinga,Chi-yuan Hsu,Regina Jordan,Nilka Ríos Burrows,Elizabeth Hedgeman,Jerry Yee,Rajiv Saran,Neil R. Powe +8 more
TL;DR: Although individuals who manifest many markers of kidney dysfunction are more likely to be aware of their CKD, their CKd awareness remains low and a better understanding of mechanisms of awareness is required.
References
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Journal ArticleDOI
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C. Knowler,Elizabeth Barrett-Connor,Sarah E. Fowler,Richard F. Hamman,John M. Lachin,Elizabeth A. Walker,David M. Nathan +6 more
TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
Journal ArticleDOI
Hyperglycemia and adverse pregnancy outcomes
Boyd E. Metzger,Lynn P. Lowe,Alan R. Dyer,Elisabeth R. Trimble,Udom Chaovarindr,Donald R. Coustan,David R. Hadden,David R. McCance,Moshe Hod,Harold David McIntyre,Jeremy Oats,Bengt Persson,Michael S. Rogers,David A. Sacks +13 more
TL;DR: The results indicate strong, continuous associations of maternal glucose levels below those diagnostic of diabetes with increased birth weight and increased cord-blood serum C-peptide levels.
Journal ArticleDOI
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
Pregnancy Study Groups Consensus Panel,Boyd E. Metzger,Steven G. Gabbe,Bengt Persson,Thomas A. Buchanan,Patrick A Catalano,Peter Damm,Alan R. Dyer,Alberto de Leiva,Moshe Hod,John L Kitzmiler,Lynn P. Lowe,H. David McIntyre,Jeremy Oats,Yasue Omori,Maria Inês Schmidt +15 more
TL;DR: The Brazilian study provided evidence that adverse perinatal outcomes are associated with levels of maternal glycemia below those diagnostic of GDM by American Diabetes Association or World Health Organization criteria, however, the results were potentially confounded by the treatment of G DM.
Journal ArticleDOI
Follow-up report on the diagnosis of diabetes mellitus.
Saul Genuth,K. G. M. M. Alberti,Peter H. Bennett,John B. Buse,Ralph A. DeFronzo,Richard Kahn,John L. Kitzmiller,William C. Knowler,Harold E. Lebovitz,Åke Lernmark,David M. Nathan,Jerry P. Palmer,Robbert Rizza,Christopher D Saudek,Jonathan E. Shaw,Michael W. Steffes,Michael P. Stern,Jaakko Tuomilehto,Paul Zimmet +18 more
TL;DR: The International Expert Committee was convened to reexamine the classification and diagnostic criteria of diabetes, which were based on the 1979 publication of the National Diabetes Data Group and subsequent WHO study group and adopted several changes to the diagnostic criteria for diabetes and for lesser degrees of impaired glucose regulation (IFG/IGT).
Journal ArticleDOI
Effect of treatment of gestational diabetes mellitus on pregnancy outcomes
Caroline A Crowther,Janet E. Hiller,John R. Moss,Andrew J McPhee,William S. Jeffries,Jeffrey S. Robinson +5 more
TL;DR: Treatment of gestational diabetes reduces serious perinatal morbidity and may also improve the woman's health-related quality of life.
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