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Open AccessJournal ArticleDOI

Diagnosis and Classification of Diabetes Mellitus

Vittorio Basevi
- 06 Feb 2011 - 
TLDR
The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
About
This article is published in Diabetes Care.The article was published on 2011-02-06 and is currently open access. It has received 13077 citations till now. The article focuses on the topics: Prediabetes & Impaired fasting glucose.

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Citations
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Prävalenz und zeitliche Entwicklung des bekannten Diabetes mellitus

TL;DR: The first wave of the “German Health Interview and Examination Survey for Adults” allows for up-to-date, representative prevalence estimates of known diabetes amongst the 18- to 79-year-old resident population of Germany.
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Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression.

TL;DR: It is indicated that NAFPD is a frequent clinical entity, associated with significantly increased risk of metabolic syndrome and its components, and the normal pancreatic fat percentage threshold of 6.2% may be recommended for use in future prospective studies.
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Sclerostin levels associated with inhibition of the Wnt/β-catenin signaling and reduced bone turnover in type 2 diabetes mellitus.

TL;DR: The results show for the first time that T2DM patients have serum concentrations of β-catenin lower than controls, which suggests a biological effect of increased sclerostin on the Wnt signaling, which appears impaired in T2 DM.
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Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk.

TL;DR: It is unknown whether human obesity affects circulating Treg cells and whether their number is associated with markers of systemic inflammation or glucose intolerance, but reduced numbers of regulatory T (Treg) cells have been observed in visceral adipose tissue of obese mice and humans.
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Genetics of diabetes--are we missing the genes or the disease?

TL;DR: Potential sources of this missing heritability are discussed and the possibility that the definition of diabetes and its subgroups is imprecise and thereby making the identification of genetic causes difficult is discussed.
References
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Journal ArticleDOI

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.

TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
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International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.

TL;DR: The Brazilian study provided evidence that adverse perinatal outcomes are associated with levels of maternal glycemia below those diagnostic of GDM by American Diabetes Association or World Health Organization criteria, however, the results were potentially confounded by the treatment of G DM.
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Follow-up report on the diagnosis of diabetes mellitus.

TL;DR: The International Expert Committee was convened to reexamine the classification and diagnostic criteria of diabetes, which were based on the 1979 publication of the National Diabetes Data Group and subsequent WHO study group and adopted several changes to the diagnostic criteria for diabetes and for lesser degrees of impaired glucose regulation (IFG/IGT).
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Effect of treatment of gestational diabetes mellitus on pregnancy outcomes

TL;DR: Treatment of gestational diabetes reduces serious perinatal morbidity and may also improve the woman's health-related quality of life.
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