Diagnosis and Classification of Diabetes Mellitus
TLDR
The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.About:
This article is published in Diabetes Care.The article was published on 2011-02-06 and is currently open access. It has received 13077 citations till now. The article focuses on the topics: Prediabetes & Impaired fasting glucose.read more
Citations
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Prävalenz und zeitliche Entwicklung des bekannten Diabetes mellitus
TL;DR: The first wave of the “German Health Interview and Examination Survey for Adults” allows for up-to-date, representative prevalence estimates of known diabetes amongst the 18- to 79-year-old resident population of Germany.
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Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression.
TL;DR: It is indicated that NAFPD is a frequent clinical entity, associated with significantly increased risk of metabolic syndrome and its components, and the normal pancreatic fat percentage threshold of 6.2% may be recommended for use in future prospective studies.
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Sclerostin levels associated with inhibition of the Wnt/β-catenin signaling and reduced bone turnover in type 2 diabetes mellitus.
Agostino Gaudio,F. Privitera,Katia Battaglia,Venerando Torrisi,Maria Helga Sidoti,Ivana Pulvirenti,Elena Canzonieri,Giovanni Tringali,Carmelo Erio Fiore +8 more
TL;DR: The results show for the first time that T2DM patients have serum concentrations of β-catenin lower than controls, which suggests a biological effect of increased sclerostin on the Wnt signaling, which appears impaired in T2 DM.
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Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk.
Nana-Maria Wagner,Gunnar Brandhorst,Frauke S. Czepluch,Mareike Lankeit,Christoph Eberle,Sebastian Herzberg,Vivien Faustin,Joachim Riggert,Michael Oellerich,Gerd Hasenfuss,Stavros Konstantinides,Katrin Schäfer +11 more
TL;DR: It is unknown whether human obesity affects circulating Treg cells and whether their number is associated with markers of systemic inflammation or glucose intolerance, but reduced numbers of regulatory T (Treg) cells have been observed in visceral adipose tissue of obese mice and humans.
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Genetics of diabetes--are we missing the genes or the disease?
Leif Groop,Flemming Pociot +1 more
TL;DR: Potential sources of this missing heritability are discussed and the possibility that the definition of diabetes and its subgroups is imprecise and thereby making the identification of genetic causes difficult is discussed.
References
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Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
William C. Knowler,Elizabeth Barrett-Connor,Sarah E. Fowler,Richard F. Hamman,John M. Lachin,Elizabeth A. Walker,David M. Nathan +6 more
TL;DR: In this paper, the authors compared a lifestyle intervention with metformin to prevent or delay the development of Type 2 diabetes in nondiabetic individuals. And they found that the lifestyle intervention was significantly more effective than the medication.
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Hyperglycemia and adverse pregnancy outcomes
Boyd E. Metzger,Lynn P. Lowe,Alan R. Dyer,Elisabeth R. Trimble,Udom Chaovarindr,Donald R. Coustan,David R. Hadden,David R. McCance,Moshe Hod,Harold David McIntyre,Jeremy Oats,Bengt Persson,Michael S. Rogers,David A. Sacks +13 more
TL;DR: The results indicate strong, continuous associations of maternal glucose levels below those diagnostic of diabetes with increased birth weight and increased cord-blood serum C-peptide levels.
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International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
Pregnancy Study Groups Consensus Panel,Boyd E. Metzger,Steven G. Gabbe,Bengt Persson,Thomas A. Buchanan,Patrick A Catalano,Peter Damm,Alan R. Dyer,Alberto de Leiva,Moshe Hod,John L Kitzmiler,Lynn P. Lowe,H. David McIntyre,Jeremy Oats,Yasue Omori,Maria Inês Schmidt +15 more
TL;DR: The Brazilian study provided evidence that adverse perinatal outcomes are associated with levels of maternal glycemia below those diagnostic of GDM by American Diabetes Association or World Health Organization criteria, however, the results were potentially confounded by the treatment of G DM.
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Follow-up report on the diagnosis of diabetes mellitus.
Saul Genuth,K. G. M. M. Alberti,Peter H. Bennett,John B. Buse,Ralph A. DeFronzo,Richard Kahn,John L. Kitzmiller,William C. Knowler,Harold E. Lebovitz,Åke Lernmark,David M. Nathan,Jerry P. Palmer,Robbert Rizza,Christopher D Saudek,Jonathan E. Shaw,Michael W. Steffes,Michael P. Stern,Jaakko Tuomilehto,Paul Zimmet +18 more
TL;DR: The International Expert Committee was convened to reexamine the classification and diagnostic criteria of diabetes, which were based on the 1979 publication of the National Diabetes Data Group and subsequent WHO study group and adopted several changes to the diagnostic criteria for diabetes and for lesser degrees of impaired glucose regulation (IFG/IGT).
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Effect of treatment of gestational diabetes mellitus on pregnancy outcomes
Caroline A Crowther,Janet E. Hiller,John R. Moss,Andrew J McPhee,William S. Jeffries,Jeffrey S. Robinson +5 more
TL;DR: Treatment of gestational diabetes reduces serious perinatal morbidity and may also improve the woman's health-related quality of life.
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