Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility.
Jana Vitku,Lucie Sosvorova,Tereza Chlupacova,Richard Hampl,Martin Hill,Vladimír Sobotka,Jiri Heracek,M Bičíková,Luboslav Stárka +8 more
TLDR
Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration, and this point to the importance of seminal plasma in BPA research.Abstract:
The general population is potentially exposed to many chemicals that can affect the endocrine system. These substances are called endocrine disruptors (EDs), and among them bisphenol A (BPA) is one of the most widely used and well studied. Nonetheless, there are still no data on simultaneous measurements of various EDs along with steroids directly in the seminal fluid, where deleterious effects of EDs on spermatogenesis and steroidogenesis are assumed. We determined levels of BPA and 3 estrogens using LC-MS/MS in the plasma and seminal plasma of 174 men with different degrees of infertility. These men were divided according their spermiogram values into 4 groups: (1) healthy men, and (2) slightly, (3) moderate, and (4) severely infertile men. Estradiol levels differed across the groups and body fluids. Slightly infertile men have significantly higher BPA plasma and seminal plasma levels in comparison with healthy men (p<0.05 and p<0.01, respectively). Furthermore, seminal BPA, but not plasma BPA, was negatively associated with sperm concentration and total sperm count (-0.27; p<0.001 and -0.24; p<0.01, respectively). These findings point to the importance of seminal plasma in BPA research. Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration.read more
Citations
More filters
Journal ArticleDOI
Determination of selected bisphenols, parabens and estrogens in human plasma using LC-MS/MS.
Lucie Sosvorova,Tereza Chlupacova,Jana Vitku,Martin Vlk,Jiri Heracek,Luboslav Stárka,David Šaman,Marketa Simkova,Richard Hampl +8 more
TL;DR: This is the first method allowing the determination of plasma bisphenols, parabens and estrogens in one run, and also the first determination of BPF levels in human plasma.
Journal ArticleDOI
Urinary Bisphenol A Levels and Male Fertility.
Michał Radwan,Bartosz Wielgomas,Emila Dziewirska,Paweł Radwan,Paweł Kałużny,Anna Klimowska,Wojciech Hanke,Joanna Jurewicz +7 more
TL;DR: The study provides evidence that exposure to BPA is associated with poorer semen quality, and when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy and increase the percentage of immature sperm.
Journal ArticleDOI
Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder?
Jian-Sheng Xing,Zhi-Ming Bai +1 more
TL;DR: It is revealed that environmental exposures owing to modern lifestyles are primary factors involved in the associated trends of the syndrome, which are capable of affecting the adult endocrine system via direct means or through epigenetic mechanisms.
Journal ArticleDOI
Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution – a review
Tereza Žalmanová,Kristýna Hošková,Jan Nevoral,Šárka Prokešová,K. Zámostná,Tomáš Kott,Jaroslav Petr +6 more
TL;DR: There is a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced.
Journal ArticleDOI
Preconception Seminal Plasma Concentrations of Endocrine Disrupting Chemicals in Relation to Semen Quality Parameters Among Male Partners Planning for Pregnancy
Melissa M. Smarr,Melissa M. Smarr,Kurunthachalam Kannan,Liping Sun,Masato Honda,Wei Wang,Rajendiran Karthikraj,Zhen Chen,Jennifer Weck,Germaine M. Buck Louis +9 more
TL;DR: Environmentally relevant concentrations of specific phthalates in seminal plasma were associated with diminished semen volume, sperm motility, viability, and morphological alterations in sperm heads such that semen volume and sperm viability fall below reference values.
References
More filters
Journal ArticleDOI
Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust.
TL;DR: This study provides a basis for prioritizing toxicology and exposure research for individual EDCs and mixtures and provides new tools for exposure assessment in health studies.
Journal ArticleDOI
Metabolism and kinetics of bisphenol a in humans at low doses following oral administration.
TL;DR: The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bispenol A in humans following oral absorption of low doses.
Journal ArticleDOI
In vitro molecular mechanisms of bisphenol A action.
Yelena B. Wetherill,Benson T. Akingbemi,Jun Kanno,John A. McLachlan,Angel Nadal,Carlos Sonnenschein,Cheryl S. Watson,R. Thomas Zoeller,Scott M. Belcher +8 more
TL;DR: This review is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.
Journal ArticleDOI
Large Effects from Small Exposures. I. Mechanisms for Endocrine-Disrupting Chemicals with Estrogenic Activity
Wade V. Welshons,Kristina A. Thayer,Barbara M. Judy,Julia A. Taylor,Edward M. Curran,Frederick S. vom Saal +5 more
TL;DR: Four fundamental issues are problematic for risk assessment methods used by regulatory agencies, because they challenge the traditional use of extrapolation from high-dose testing to predict responses at the much lower environmentally relevant doses.
Journal ArticleDOI
Thyroid hormone action is disrupted by bisphenol A as an antagonist.
Kenji Moriyama,Tetsuya Tagami,Takashi Akamizu,Takeshi Usui,Misa Saijo,Naotetsu Kanamoto,Yuji Hataya,Akira Shimatsu,Hideshi Kuzuya,Kazuwa Nakao +9 more
TL;DR: The results suggest that BPA could displace T(3) from the TR and recruit a transcriptional repressor, resulting in gene suppression, the first report that B PA can antagonize T( 3) action at the transcriptional level.