Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility.
Jana Vitku,Lucie Sosvorova,Tereza Chlupacova,Richard Hampl,Martin Hill,Vladimír Sobotka,Jiri Heracek,M Bičíková,Luboslav Stárka +8 more
TLDR
Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration, and this point to the importance of seminal plasma in BPA research.Abstract:
The general population is potentially exposed to many chemicals that can affect the endocrine system. These substances are called endocrine disruptors (EDs), and among them bisphenol A (BPA) is one of the most widely used and well studied. Nonetheless, there are still no data on simultaneous measurements of various EDs along with steroids directly in the seminal fluid, where deleterious effects of EDs on spermatogenesis and steroidogenesis are assumed. We determined levels of BPA and 3 estrogens using LC-MS/MS in the plasma and seminal plasma of 174 men with different degrees of infertility. These men were divided according their spermiogram values into 4 groups: (1) healthy men, and (2) slightly, (3) moderate, and (4) severely infertile men. Estradiol levels differed across the groups and body fluids. Slightly infertile men have significantly higher BPA plasma and seminal plasma levels in comparison with healthy men (p<0.05 and p<0.01, respectively). Furthermore, seminal BPA, but not plasma BPA, was negatively associated with sperm concentration and total sperm count (-0.27; p<0.001 and -0.24; p<0.01, respectively). These findings point to the importance of seminal plasma in BPA research. Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration.read more
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The adverse health effects of bisphenol A and related toxicity mechanisms.
Ya Ma,Haohao Liu,Jinxia Wu,Le Yuan,Yueqin Wang,Xingde Du,Rui Wang,Phelisters Wegesa Marwa,Pavankumar Petlulu,Xinghai Chen,Huizhen Zhang +10 more
TL;DR: The underlying mechanisms of BPA-induced multi-organ toxicity were well summarized, involving the receptor pathways, disruption of neuroendocrine system, inhibition of enzymes, modulation of immune and inflammatory responses, as well as genotoxic and epigenetic mechanisms.
Journal ArticleDOI
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
Ilaria Cimmino,Francesca Fiory,Giuseppe Perruolo,Claudia Miele,Francesco Beguinot,Pietro Formisano,Francesco Oriente +6 more
TL;DR: This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.
Journal ArticleDOI
Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic
Jana Vitku,Jiri Heracek,Lucie Sosvorova,Richard Hampl,Tereza Chlupacova,Martin Hill,Vladimír Sobotka,Marie Bičíková,Luboslav Stárka +8 more
TL;DR: The data indicate that BPA influences human gonadal and adrenal steroidogenesis at various steps, and may negatively contribute to the final state of sperm quality.
Journal ArticleDOI
Effects of bisphenol A on male and couple reproductive health: a review
TL;DR: Overall, the evidence supporting an association between BPA exposure and adverse male reproductive health outcomes in humans remains limited and inconclusive.
Journal ArticleDOI
"Bisphenol a: an emerging threat to male fertility"
Federica Cariati,Nadja D’Uonno,Francesca Borrillo,Stefania Iervolino,Giacomo Galdiero,Rossella Tomaiuolo +5 more
TL;DR: In this paper, a review of the current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action.
References
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Urinary bisphenol A and semen quality, the LIFE Study
Alexandra E. Goldstone,Zhen Chen,Melissa J. Perry,Kurunthachalam Kannan,Germaine M. Buck Louis +4 more
TL;DR: A negative relation between BPA and DNA fragmentation was the sole significant finding in adjusted linear regression and suggestive of less sperm DNA damage.
Book ChapterDOI
Nuclear Receptor Profiling of Bisphenol-A and Its Halogenated Analogues
Vanessa Delfosse,Marina Grimaldi,Albane le Maire,William Bourguet,William Bourguet,Patrick Balaguer +5 more
TL;DR: Recent studies shedding light on the structural and molecular mechanisms by which BPA and its halogenated derivatives interfere with nuclear hormone receptor signaling provide guidelines for the development of safer substitutes devoid of hormonal activity and may help environmental risk assessment.
Journal ArticleDOI
Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction
TL;DR: Urinary BPA concentrations in male partners of subfertile couples may influence semen quality parameters, but do not affect embryo development up to the blastocyst stage after medically assisted reproduction.
Journal ArticleDOI
Development of stable isotope dilution quantification liquid chromatography-mass spectrometry method for estimation of exposure levels of bisphenol A, 4-tert-octylphenol, 4-nonylphenol, tetrabromobisphenol A, and pentachlorophenol in indoor air.
TL;DR: The findings suggest that the LC-MS method can detect low levels of phenolic xenoestrogens in air samples and that these trace levels of analytes exist in indoor air.
Journal ArticleDOI
Bisphenol A disrupts gene expression in human placental trophoblast cells.
TL;DR: It is demonstrated that BPA severely disrupts human placental gene expression in vitro, which suggests that exposure to BPA may contribute to altered placental function and consequent pregnancy complications.