Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility.
Jana Vitku,Lucie Sosvorova,Tereza Chlupacova,Richard Hampl,Martin Hill,Vladimír Sobotka,Jiri Heracek,M Bičíková,Luboslav Stárka +8 more
TLDR
Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration, and this point to the importance of seminal plasma in BPA research.Abstract:
The general population is potentially exposed to many chemicals that can affect the endocrine system. These substances are called endocrine disruptors (EDs), and among them bisphenol A (BPA) is one of the most widely used and well studied. Nonetheless, there are still no data on simultaneous measurements of various EDs along with steroids directly in the seminal fluid, where deleterious effects of EDs on spermatogenesis and steroidogenesis are assumed. We determined levels of BPA and 3 estrogens using LC-MS/MS in the plasma and seminal plasma of 174 men with different degrees of infertility. These men were divided according their spermiogram values into 4 groups: (1) healthy men, and (2) slightly, (3) moderate, and (4) severely infertile men. Estradiol levels differed across the groups and body fluids. Slightly infertile men have significantly higher BPA plasma and seminal plasma levels in comparison with healthy men (p<0.05 and p<0.01, respectively). Furthermore, seminal BPA, but not plasma BPA, was negatively associated with sperm concentration and total sperm count (-0.27; p<0.001 and -0.24; p<0.01, respectively). These findings point to the importance of seminal plasma in BPA research. Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration.read more
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The adverse health effects of bisphenol A and related toxicity mechanisms.
Ya Ma,Haohao Liu,Jinxia Wu,Le Yuan,Yueqin Wang,Xingde Du,Rui Wang,Phelisters Wegesa Marwa,Pavankumar Petlulu,Xinghai Chen,Huizhen Zhang +10 more
TL;DR: The underlying mechanisms of BPA-induced multi-organ toxicity were well summarized, involving the receptor pathways, disruption of neuroendocrine system, inhibition of enzymes, modulation of immune and inflammatory responses, as well as genotoxic and epigenetic mechanisms.
Journal ArticleDOI
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.
Ilaria Cimmino,Francesca Fiory,Giuseppe Perruolo,Claudia Miele,Francesco Beguinot,Pietro Formisano,Francesco Oriente +6 more
TL;DR: This review aims to provide an extensive and comprehensive analysis of the most recent evidence about the potential mechanisms by which BPA affects human health.
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Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic
Jana Vitku,Jiri Heracek,Lucie Sosvorova,Richard Hampl,Tereza Chlupacova,Martin Hill,Vladimír Sobotka,Marie Bičíková,Luboslav Stárka +8 more
TL;DR: The data indicate that BPA influences human gonadal and adrenal steroidogenesis at various steps, and may negatively contribute to the final state of sperm quality.
Journal ArticleDOI
Effects of bisphenol A on male and couple reproductive health: a review
TL;DR: Overall, the evidence supporting an association between BPA exposure and adverse male reproductive health outcomes in humans remains limited and inconclusive.
Journal ArticleDOI
"Bisphenol a: an emerging threat to male fertility"
Federica Cariati,Nadja D’Uonno,Francesca Borrillo,Stefania Iervolino,Giacomo Galdiero,Rossella Tomaiuolo +5 more
TL;DR: In this paper, a review of the current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action.
References
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Journal ArticleDOI
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TL;DR: The pattern of associations between BPA and reproductive hormones could indicate an antiandrogenic or antiestrogenic effect, or both, of BPA on the hypothalamic–pituitary–gonadal hormone feedback system, possibly through a competitive inhibition at the receptor level.
Journal ArticleDOI
Bisphenol A affects androgen receptor function via multiple mechanisms.
Christina T. Teng,Bonnie L. Goodwin,Keith R. Shockley,Menghang Xia,Ruili Huang,John D. Norris,B. Alex Merrick,Anton M. Jetten,Christopher P. Austin,Raymond R. Tice +9 more
TL;DR: The results showed that two receptors, estrogen receptor alpha (ERα) and androgen receptor (AR), are affected by BPA in opposite direction and BPA was unable to induce functional foci in the nuclei and is consistent with the transient transfection study that BPA is unable to activate AR.
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Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect.
Anna Pereira-Fernandes,Heidi Demaegdt,Karine Vandermeiren,Tine L.M. Hectors,Philippe G. Jorens,Ronny Blust,Caroline Vanparys +6 more
TL;DR: A standardised protocol for obesogen screening based on the 3T3-L1 cell line, a well-characterised adipogenesis model, and direct fluorescent measurement using Nile red lipid staining technique is suggested, showing the adipogenic potential of all tested parabens, several musks and phthalate compounds and BPA.
Journal ArticleDOI
Handling of Thermal Receipts as a Source of Exposure to Bisphenol A
Shelley Ehrlich,Shelley Ehrlich,Antonia M. Calafat,Olivier Humblet,Thomas E. Smith,Russ Hauser +5 more
TL;DR: It is hypothesized that handling of thermal receipts significantly increases BPA exposure, but use of gloves during handling minimizes exposure.