Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.
Hing-C. Wong,Audrey Bourdelas,Anke Krauss,Ho-Jin Lee,Youming Shao,Dianqing Wu,Marek Mlodzik,De-Li Shi,Jie Zheng,Jie Zheng +9 more
TLDR
Differences in the binding affinity of the Dvl PDZ domain and its binding partners may be important in regulating signal transduction by Dvl, and these results identify a missing molecular connection within the Wnt pathway.About:
This article is published in Molecular Cell.The article was published on 2003-11-01 and is currently open access. It has received 521 citations till now. The article focuses on the topics: Frizzled & Dishevelled.read more
Citations
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The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
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Wnt/β-catenin signaling: components, mechanisms, and diseases
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
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Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
Michael D. Gordon,Roel Nusse +1 more
TL;DR: The majority of work in the field to date has focused on -catenin-dependent, or canonical, Wnt signaling, but examples continue to accumulate in which Wnts and/or other key components of the canonical signaling cascade participate in -catanin-independent processes.
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Wnt signal transduction pathways
Yuko Komiya,Raymond Habas +1 more
TL;DR: The most recent advances in understanding of these Wnt signaling pathways are summarized and the role of these pathways in regulating key events during embryonic patterning and morphogenesis is summarized.
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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way
TL;DR: This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Llrp6 in Wnt signaling, and discusses Arrows interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular β-catenin degradation apparatus.
References
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TL;DR: The asynchronous pipeline scheme provides other substantial advantages, including high flexibility, favorable processing speeds, choice of both all-in-memory and disk-bound processing, easy adaptation to different data formats, simpler software development and maintenance, and the ability to distribute processing tasks on multi-CPU computers and computer networks.
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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Torsion angle dynamics for nmr structure calculation with the new program dyana
TL;DR: Test calculations starting from conformers with random torsion angle values showed that DYANA is capable of efficient calculation of high-quality protein structures with up to 400 amino acid residues, and of nucleic acid structures.
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Wnt signaling: a common theme in animal development
Ken M. Cadigan,Roel Nusse +1 more
TL;DR: Current understanding of Wnt function and signaling mechanisms is reviewed in a comparative approach, highlighting novelty and underscoring questions that remain, and putting emphasis on the latest findings.
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The Hedgehog and Wnt signalling pathways in cancer
Jussi Taipale,Philip A. Beachy +1 more
TL;DR: Evidence suggesting that tumorigenesis associated with pathway activation may result from mis-specification of cells towards stem-cell or stem cell-like fates is reviewed.