Journal ArticleDOI
Disturbed feto-maternal cell traffic in preeclampsia.
TLDR
The results suggest that the trafficking of fetal cells into the maternal periphery is disturbed in patients with preeclampsia, and may lead to interesting new concepts regarding the development of preeClampsia and possibly the associated syndrome of hemolysis, elevated liver enzymes, and low platelets.About:Â
This article is published in Obstetrics & Gynecology.The article was published on 1998-05-01. It has received 248 citations till now. The article focuses on the topics: Preeclampsia & Fetus.read more
Citations
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Journal ArticleDOI
Circulating Angiogenic Factors and the Risk of Preeclampsia
Richard J. Levine,Sharon Maynard,Cong Qian,Kee-Hak Lim,Lucinda England,Kai F. Yu,Enrique F. Schisterman,Ravi Thadhani,Benjamin P. Sachs,Franklin H. Epstein,Bahaeddine M Sibai,Vikas P. Sukhatme,S. Ananth Karumanchi +12 more
TL;DR: Alterations in the levels of sFlt-1 and free PlGF were greater in women with an earlier onset of preeclampsia and in women in whom preeClampsia was associated with a small-for-gestational-age infant.
Journal ArticleDOI
The preterm parturition syndrome
Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Francesca Gotsch,Sonia S. Hassan,Offer Erez,Tinnakorn Chaiworapongsa,Moshe Mazor +7 more
TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophinâreleasing factor related).
Journal ArticleDOI
Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema.
TL;DR: Systemic features in PRES appear to render strong support for the older theory of vasoconstriction coupled with hypoperfusion as the mechanism, including supporting evidence and current available imaging/clinical data related to the conditions that develop PRES.
Journal ArticleDOI
Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia
Y.M. Dennis Lo,Tse N. Leung,Mark S.C. Tein,Ian L. Sargent,Jun Zhang,Tze K. Lau,Christopher J. Haines,Christopher W.G. Redman +7 more
TL;DR: The results suggest that preeclampsia is associated with disturbances in the liberation and/or clearance mechanisms of circulating DNA and raise the possibility that measurement of circulatingDNA may prove useful as a marker for the diagnosis and/ or monitoring of preeClampsia.
Journal ArticleDOI
Microchimerism of maternal origin persists into adult life
Sean Maloney,Anajane G. Smith,Daniel E. Furst,David Myerson,Kate Rupert,Paul C. Evans,J. Lee Nelson +6 more
TL;DR: Sensitive human leukocyte antigen-specific PCR assays and targeted nonshared maternal HLA genes to test for persistent maternal microchimerism indicate that HLA-disparate maternal cells can persist in immunocompetent offspring well into adult life.
References
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Journal ArticleDOI
The classification and definition of the hypertensive disorders of pregnancy.
D. A. Davey,Ian MacGillivray +1 more
TL;DR: It is hoped that this clinical classification and associated definitions will find general acceptance so that the incidence and outcome of the hypertensive disorders of pregnancy and the results of research in different centers may be compared and mutual understanding achieved.
Journal ArticleDOI
Implantation and the placenta: key pieces of the development puzzle
TL;DR: The mammalian embryo cannot develop without the placenta, which binds the embryo to the uterus and redirects maternal endocrine, immune, and metabolic functions to the embryo's advantage.
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Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum
TL;DR: The data demonstrate the continued maternal circulation of fetalCD34+ or CD34+CD38+ cells from a prior pregnancy, which may represent a human analogue of the microchimerism described in the mouse and may have significance in development of tolerance of the fetus.
Journal Article
The role of the spiral arteries in the pathogenesis of preeclampsia.
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Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.
TL;DR: Lowering oxygen tension to 2% did not change many of the cells' basic processes, but there was a marked increase in their incorporation of [3H]thymidine and 5-bromo-2'-deoxyuridine (BrdU), suggesting that oxygen tension plays an important role in regulating these processes in vivo.