Open AccessJournal Article
DNA Damage in Liver, Kidney, Bone Marrow, and Spleen of Rats and Mice Treated with Commercial and Purified Aniline as Determined by Alkaline Elution Assay and Sister Chromatid Exchange Induction
Silvio Parodi,Mauro Pala,P. Russo,Annalisa Zunino,Cecilia Balbi,Adriana Albini,Federico Valerio,Maria Roberta Cimberle,Leonardo Santi +8 more
TLDR
It is found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA damage in vivo in liver and kidney of rats.Abstract:
Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA damage in vivo in liver and kidney of rats. Both the commercial and repurified product are also clearly positive in induction of sister chromatid exchanges in vivo in male Swiss mice bone marrow cells. Liver, kidney, and bone marrow DNA damage was absent in male Swiss mice.read more
Citations
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Journal ArticleDOI
Sister-chromatid exchanges: a report of the GENE-TOX program.
Samuel A. Latt,James W. Allen,Stephen E. Bloom,Anthony V. Carrano,Ernest Falke,David Kram,David Kram,Edward L. Schneider,Rhona Schreck,Raymond R. Tice,Brad Whitfield,Sheldon Wolff +11 more
TL;DR: The data support the concept that SCEs provide a useful indication of exposure, although the mechanism and biological significance of SCE formation still remain to be elucidated.
Book ChapterDOI
ICH M7: Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk
TL;DR: This draft guidance, when finalized, will represent the Food and Drug Administration's (FDA's) current thinking on this topic and does not operate to bind FDA or the public as mentioned in this paper.
Journal ArticleDOI
The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database.
Yu F. Sasaki,Kaoru Sekihashi,Fusako Izumiyama,Emi Nishidate,Ayako Saga,Kumiko Ishida,Shuji Tsuda +6 more
TL;DR: The in vivo genotoxicity in eight organs of the mouse of 208 chemicals selected from International Agency for Research on Cancer (IARC) Groups 1, 2A, 2B, 3, and 4, and from the U.S. National Toxicology Program (NTP) Carcinogenicity Database is summarized to discuss the utility of the comet assay in genetic toxicology.
Journal ArticleDOI
Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test
TL;DR: The genotoxic potencies in the two bacterial systems were correlated within the majority of the chemical classes under scrutiny, and the genot toxic potency varied over a 4.5 X 10(7)-fold range among compounds positive in the reversion test and over a 6X 10(9)-foldrange among compounds damaging E. coli DNA.
Journal ArticleDOI
Carcinogenicity of p-chloroaniline in rats and mice
TL;DR: It is confirmed that PCA was carcinogenic in male rats and male mice and increased incidences of hepatocellular adenomas or carcinomas inosed groups of male mice.
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