Journal ArticleDOI
Drug-induced liver injury following positive drug rechallenge
Julie I. Papay,Dawn Clines,Rezvan Rafi,Nancy A. Yuen,Susan D. Britt,John S Walsh,Christine M. Hunt +6 more
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TLDR
Improved identification and communication of possible drug-induced liver injury is needed to avoid potentially serious and/or fatal drug rechallenge and Clinicians should generally avoid such rechallenges.About:
This article is published in Regulatory Toxicology and Pharmacology.The article was published on 2009-06-01. It has received 73 citations till now. The article focuses on the topics: Jaundice & Adverse effect.read more
Citations
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ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
Naga Chalasani,Paul H. Hayashi,Herbert L. Bonkovsky,Victor J. Navarro,William M. Lee,Robert J. Fontana +5 more
TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Drug-induced liver injury
Raúl J. Andrade,Guruprasad P. Aithal,Einar Björnsson,Neil Kaplowitz,Gerd A. Kullak-Ublick,Dominique Larrey,Tom H. Karlsen +6 more
TL;DR: These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.
Journal ArticleDOI
Risk Factors for Idiosyncratic Drug-Induced Liver Injury
Naga Chalasani,Einar Björnsson +1 more
TL;DR: DILI is challenging to investigate because of its rarity, the lack of experimental models, the number of medications that might cause it, and challenges to diagnosis.
Journal ArticleDOI
Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop.
Robert J. Fontana,Leonard B. Seeff,Raúl J. Andrade,Einar Björnsson,Christopher P. Day,Jose Serrano,Jay H. Hoofnagle +6 more
TL;DR: In this article, a clinical research workshop was held to review and attempt to standardize the current nomenclature and terminology used in DILI research, and a web-of-knowledge database was developed to provide concise, reliable, and updated information on cases of liver injury due to drugs and herbal and dietary supplements.
Journal ArticleDOI
Clinical Biochemistry of Hepatotoxicity
TL;DR: The present review describes the biotransformation of hepatotoxicants and various models used to study hepatotoxicity and provides an overview of pathological and biochemical mechanism involved during hepatot toxicity together with alteration of clinical biochemistry during liver injury.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period
Raúl J. Andrade,M. Isabel Lucena,M. Carmen Fernández,G. Pelaez,Ketevan Pachkoria,Elena García-Ruiz,B. García-Muñoz,Rocío González-Grande,Angeles Pizarro,José Antonio Durán,Manuel Jimenez,Luis Rodrigo,Manuel Romero-Gómez,J.M. Navarro,Ramon Planas,Joan Costa,Africa Borras,Aina Soler,Javier Salmerón,Rafael Martín-Vivaldi +19 more
TL;DR: Patients with drug-induced hepatocellular jaundice have 11.7% chance of progressing to death or transplantation, and amoxicillin-clavulanate stands out as the most common drug related to DILI.
Journal ArticleDOI
Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease.
TL;DR: These data suggest that the potential for serious hepatic toxicity can be reduced through careful monitoring of ALT levels in patients who may benefit from tacrine therapy.
Journal ArticleDOI
Drug-Induced Liver Injury
Gebran Abboud,Neil Kaplowitz +1 more
TL;DR: Mitigating the potential for drug-induced liver injury is achieved by the identification of toxicity signals during clinical trials and the monitoring of liver tests in clinical practice.
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Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period
Raúl J. Andrade,M. Isabel Lucena,M. Carmen Fernández,G. Pelaez,Ketevan Pachkoria,Elena García-Ruiz,B. García-Muñoz,Rocío González-Grande,Angeles Pizarro,José Antonio Durán,Manuel Jimenez,Luis Rodrigo,Manuel Romero-Gómez,J.M. Navarro,Ramon Planas,Joan Costa,Africa Borras,Aina Soler,Javier Salmerón,Rafael Martín-Vivaldi +19 more
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more