EASL Clinical Practice Guidelines: Drug-induced liver injury
Raúl J. Andrade,Guruprasad P. Aithal,Einar Björnsson,Neil Kaplowitz,Gerd A. Kullak-Ublick,Dominique Larrey,Tom H. Karlsen +6 more
TLDR
These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.About:
This article is published in Journal of Hepatology.The article was published on 2019-06-01 and is currently open access. It has received 504 citations till now. The article focuses on the topics: Liver disease.read more
Citations
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COVID-19: Abnormal liver function tests.
Qingxian Cai,Deliang Huang,Hong Yu,Zhibin Zhu,Zhang Xia,Yinan Su,Zhiwei Li,Guangde Zhou,Jizhou Gou,Jiuxin Qu,Yan Sun,Yingxia Liu,Qing He,Jun Chen,Lei Liu,Lin Xu +15 more
TL;DR: A high prevalence of liver test abnormalities and liver injury was observed in 417 patients with COVID-19 admitted to the only referral hospital in Shenzhen, China and the prevalence increased substantially during hospitalization.
Journal ArticleDOI
COVID-19 in a designated infectious diseases hospital outside Hubei Province, China.
Qingxian Cai,Deliang Huang,Pengcheng Ou,Hong Yu,Zhibin Zhu,Zhang Xia,Yinan Su,Zhenghua Ma,Yiming Zhang,Zhiwei Li,Qing He,Lei Liu,Yang Fu,Jun Chen +13 more
TL;DR: The clinical characteristics of novel coronavirus disease (COVID‐2019) patients outside the epicenter of Hubei Province are less understood.
Journal ArticleDOI
Drug-induced liver injury
Raúl J. Andrade,Naga Chalasani,Einar Bjornsson,Ayako Suzuki,Ayako Suzuki,Gerd A. Kullak-Ublick,Gerd A. Kullak-Ublick,Paul B. Watkins,Harshad Devarbhavi,Michael Merz,Michael Merz,M. Isabel Lucena,Neil Kaplowitz,Guruprasad P. Aithal +13 more
TL;DR: Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use as discussed by the authors.
Journal ArticleDOI
The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality
TL;DR: The European Association for the Study of the Liver (EASL) proposed a framework for the principal actions required to improve liver health in Europe as mentioned in this paper , which can serve as a powerful mechanism for improving liver care in Europe.
Journal ArticleDOI
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Jonel Trebicka,Javier Romaní Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Christian Jansen,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Peter Jarcuska,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,Debbie L. Shawcross,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Karen Vagner Danielsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Haluk Tarik Kani,Sven Francque,Stephen D. Ryder,Pierre Nahon,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia-Lopez,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Michael Praktiknjo,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,William Bernal,Ferran Aguilar,Joan Clària,Paola Ponzo,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Alexander L. Gerbes,Victor Vargas,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Richard Moreau,Paolo Angeli,Rajiv Jalan,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Maximilian J. Brol,Johannes Chang,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Martin Janicko,Daniel Markwardt,Mattias Mandorfer,Christoph Welsch,T.M. Welzel,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Flemming Bendtsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Joerg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Luise Aamann,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Harald Rupprechter,Cornelius Engelmann,Osman Ozdogan +130 more
TL;DR: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD and specific preventive and therapeutic strategies targeting these events may improve outcome in decompensated cirrhosis.
References
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Journal ArticleDOI
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin,Vanna Chiarion-Sileni,Rene Gonzalez,Jean-Jacques Grob,C. Lance Cowey,Christopher D. Lao,Dirk Schadendorf,Reinhard Dummer,Michael Smylie,Piotr Rutkowski,Pier Francesco Ferrucci,A. Hill,John Wagstaff,Matteo S. Carlino,John B A G Haanen,Michele Maio,Ivan Marquez-Rodas,Grant A. McArthur,Paolo A. Ascierto,Georgina V. Long,Margaret K. Callahan,Michael A. Postow,Michael A. Postow,Kenneth F. Grossmann,Mario Sznol,Brigitte Dréno,Lars Bastholt,Arvin Yang,Linda Rollin,Christine Horak,F. Stephen Hodi,Jedd D. Wolchok,Jedd D. Wolchok +32 more
TL;DR: Among previously untreated patients with metastatic melanoma, nivolumab alone or combined with ipilimumab resulted in significantly longer progression-free survival than ipILimumab alone, and in patients with PD-L1-negative tumors, the combination of PD-1 and CTLA-4 blockade was more effective than either agent alone.
Journal ArticleDOI
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
Anthony B. El-Khoueiry,Bruno Sangro,Thomas Yau,Todd S. Crocenzi,Masatoshi Kudo,Chiun Hsu,Tae You Kim,Su Pin Choo,Jörg Trojan,Theodore H. Welling,Tim Meyer,Yoon-Koo Kang,Winnie Yeo,Akhil Chopra,Jeffrey Anderson,Christine Dela Cruz,Lixin Lang,Jaclyn Neely,Hao Tang,Homa Dastani,Ignacio Melero +20 more
TL;DR: Durable objective responses show the potential of nivolumab for treatment of advanced hepatocellular carcinoma, and safety and tolerability for the escalation phase and objective response rate were primary endpoints.
Journal ArticleDOI
International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis
Fernando Alvarez,P.A. Berg,Francesco B. Bianchi,Leonardo Bianchi,A.K. Burroughs,Eduardo Luiz Rachid Cançado,Roger W. Chapman,W. G. E. Cooksley,Albert J. Czaja,V J Desmet,Peter T. Donaldson,A. L. W. F. Eddleston,L. Fainboim,Jenny Heathcote,Jean-Claude Homberg,Jay H. Hoofnagle,Shinichi Kakumu,Edward L. Krawitt,Ian R. Mackay,R. N. M. Macsween,Willis C. Maddrey,Michael P. Manns,I.G. McFarlane,K H Meyer zum Büschenfelde,G. Mieli-Vergani,Yasuni Nakanuma,Mikio Nishioka,Edward Penner,Gilda Porta,Bernard Portmann,W. D. Reed,Joan Rodés,Solko W. Schalm,P. J. Scheuer,Erik Schrumpf,Takeshi Seki,Gotaro Toda,Takao Tsuji,Niels Tygstrup,Diego Vergani,Mikio Zeniya +40 more
Journal ArticleDOI
The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety
TL;DR: Safety continues to be a major issue with the use of herbal remedies and it becomes imperative, therefore, that relevant regulatory authorities put in place appropriate measures to protect public health by ensuring that all herbal medicines are safe and of suitable quality.
Journal ArticleDOI
Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
George Ostapowicz,Robert J. Fontana,Frank V. Schioødt,Anne M. Larson,Timothy J. Davern,Steven Han,Timothy M. McCashland,A. Obaid Shakil,J. Eileen Hay,Linda S. Hynan,Jeffrey S. Crippin,Andres T. Blei,Grace Samuel,Joan S. Reisch,William M. Lee,Raj Santyanarayana,Cary Caldwell,Lawton Shick,Nathan M. Bass,Smita Rouillard,E Atillasoy,Steven L. Flamm,Kent G. Benner,Hugo R. Rosen,Paul Martin,Rise Stribling,Eugene R. Schiff,Maria Torres,Victor J. Navarro,Brendan M. McGuire,Raymond T. Chung,Diane R. Abraczinskas,Jules L. Dienstag +32 more
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
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