Dynamic role of adult-born dentate granule cells in memory processing.
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It is proposed that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space, and with maturation, they would specialize to represent details of these novel inputs, favoring discrimination.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2015-12-01 and is currently open access. It has received 60 citations till now. The article focuses on the topics: Dentate gyrus & Neurogenesis.read more
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Journal ArticleDOI
Hippocampal neurogenesis: Learning to remember.
Orly Lazarov,Carolyn Hollands +1 more
TL;DR: The cognitive assessments used for the detection of Alzheimer's disease in humans and rodent models of familial Alzheimer’s disease are discussed, and their value for unraveling the mechanism underlying the development of cognitive impairments and dementia are discussed.
Journal ArticleDOI
Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits
Kathleen M. McAvoy,Kimberly N. Scobie,Stefan P Berger,Craig Russo,Nannan Guo,Pakanat Decharatanachart,Hugo Vega-Ramirez,Sam Miake-Lye,Michael J. Whalen,Mark L. Nelson,Matteo Bergami,Dusan Bartsch,René Hen,Benedikt Berninger,Amar Sahay +14 more
TL;DR: Transient genetic overexpression of a negative regulator of dendritic spines in mature D GCs enhanced integration of adult-born DGCs and increased NSC activation, which transiently reorganized adult- born DGC local afferent connectivity and promoted global remapping in the DG.
Journal ArticleDOI
A disynaptic feedback network activated by experience promotes the integration of new granule cells.
Diego E. Alvarez,Damiana Giacomini,Sung Min Yang,Mariela F. Trinchero,Silvio Gabriel Temprana,Karina A. Buttner,Natalia Beltramone,Alejandro F. Schinder +7 more
TL;DR: The results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that “prime” young GCs through a disynaptic feedback loop mediated by PV-INs.
Journal ArticleDOI
Adult Hippocampal Neurogenesis: A Coming-of-Age Story
TL;DR: This Progressions article recounts the personal view of the initial setting that led to the initial study of neurogenesis in the adult mammalian brain and discusses some of its implications and developments that followed.
Journal ArticleDOI
Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates.
TL;DR: The role that immature and mature adult-born neurons play in this circuitry is still mostly unknown but it could prove fundamental to understand hippocampal-dependent cognitive processes, the pathophysiology of depression, and the therapeutic effects of antidepressant medication in modulating behavior and mental health.
References
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Journal ArticleDOI
Neural networks and physical systems with emergent collective computational abilities
TL;DR: A model of a system having a large number of simple equivalent components, based on aspects of neurobiology but readily adapted to integrated circuits, produces a content-addressable memory which correctly yields an entire memory from any subpart of sufficient size.
Book ChapterDOI
Neural networks and physical systems with emergent collective computational abilities
TL;DR: A model of a system having a large number of simple equivalent components, based on aspects of neurobiology but readily adapted to integrated circuits, produces a content-addressable memory which correctly yields an entire memory from any subpart of sufficient size.
Journal ArticleDOI
Simple memory: a theory for archicortex.
TL;DR: It is shown that rather general numerical constraints roughly determine the dimensions of memorizing models for the mammalian brain, and from these is derived a general model for archicortex.
Journal ArticleDOI
Dynamics of Hippocampal Neurogenesis in Adult Humans
Kirsty L. Spalding,Olaf Bergmann,Kanar Alkass,Samuel Bernard,Mehran Salehpour,Hagen B. Huttner,Hagen B. Huttner,Emil Boström,Isabelle Westerlund,Céline Vial,Bruce A. Buchholz,Göran Possnert,Deborah C. Mash,Henrik Druid,Jonas Frisén +14 more
TL;DR: It is concluded that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.
Journal ArticleDOI
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Claire D. Clelland,Minee L. Choi,Carola Romberg,Gregory D. Clemenson,Alexandra M. C. Fragniere,P. Tyers,Sebastian Jessberger,Lisa M. Saksida,Roger A. Barker,Fred H. Gage,Timothy J. Bussey +10 more
TL;DR: Using adult mice in which hippocampal neurogenesis was ablated, this work found specific impairments in spatial discrimination with two behavioral assays: a spatial navigation radial arm maze task and a spatial, but non-navigable, task in the mouse touch screen.