Journal ArticleDOI
Dysregulated pH: a perfect storm for cancer progression.
TLDR
The central role of pH sensors in cancer cell adaptations is highlighted and how dysregulated pH could be exploited to develop cancer-specific therapeutics is suggested.Abstract:
Although cancer is a diverse set of diseases, cancer cells share a number of adaptive hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show a 'reversed' pH gradient with a constitutively increased intracellular pH that is higher than the extracellular pH. This gradient enables cancer progression by promoting proliferation, the evasion of apoptosis, metabolic adaptation, migration and invasion. Several new advances, including an increased understanding of pH sensors, have provided insight into the molecular basis for pH-dependent cell behaviours that are relevant to cancer cell biology. We highlight the central role of pH sensors in cancer cell adaptations and suggest how dysregulated pH could be exploited to develop cancer-specific therapeutics.read more
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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
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Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
TL;DR: It is believed that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve the ability to combat cancers.
Journal ArticleDOI
Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
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Store-Operated Calcium Channels
Murali Prakriya,Richard S. Lewis +1 more
TL;DR: This review describes the major experimental advances underlying the current understanding of how ER Ca(2+) depletion is coupled to the activation of SOCs, and particular emphasis is placed on the molecular mechanisms of STIM and Orai activation, ORAi channel properties, modulation of STim and orai function, pharmacological inhibitors of SOCE, and the functions of ST IM and Obrai in physiology and disease.
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Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2 -Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.
TL;DR: A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment by relieving hypoxia.
References
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