Early versus Late Parenteral Nutrition in Critically Ill Children.
Tom Fivez,Dorian Kerklaan,Dieter Mesotten,Sascha Verbruggen,Pieter Wouters,Ilse Vanhorebeek,Yves Debaveye,Dirk Vlasselaers,Lars Desmet,Michael P Casaer,Gonzalo Garcia Guerra,Jan Hanot,Ari R. Joffe,Dick Tibboel,Koen F. M. Joosten,Greet Van den Berghe +15 more
Reads0
Chats0
TLDR
In critically ill children, withholding parenteral nutrition for 1 week in the ICU was clinically superior to providing early parenTERal nutrition.Abstract:
BackgroundRecent trials have questioned the benefit of early parenteral nutrition in adults. The effect of early parenteral nutrition on clinical outcomes in critically ill children is unclear. MethodsWe conducted a multicenter, randomized, controlled trial involving 1440 critically ill children to investigate whether withholding parenteral nutrition for 1 week (i.e., providing late parenteral nutrition) in the pediatric intensive care unit (ICU) is clinically superior to providing early parenteral nutrition. Fluid loading was similar in the two groups. The two primary end points were new infection acquired during the ICU stay and the adjusted duration of ICU dependency, as assessed by the number of days in the ICU and as time to discharge alive from ICU. For the 723 patients receiving early parenteral nutrition, parenteral nutrition was initiated within 24 hours after ICU admission, whereas for the 717 patients receiving late parenteral nutrition, parenteral nutrition was not provided until the morning o...read more
Citations
More filters
Journal ArticleDOI
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children
Scott L. Weiss,Mark J. Peters,Waleed Alhazzani,Michael S. D. Agus,Heidi R. Flori,David Inwald,Simon Nadel,Luregn J. Schlapbach,Robert C. Tasker,Andrew C. Argent,Joe Brierley,Joseph Carcillo,Enitan D. Carrol,Christopher L. Carroll,Ira M. Cheifetz,Karen Choong,Jeffry J. Cies,Andrea T. Cruz,Daniele De Luca,Daniele De Luca,Akash Deep,Saul N. Faust,Claudio Flauzino De Oliveira,Mark W. Hall,Paul Ishimine,Etienne Javouhey,Koen F. M. Joosten,Poonam Joshi,Oliver Karam,Martin C. J. Kneyber,Joris Lemson,Graeme MacLaren,Nilesh M. Mehta,Morten Hylander Møller,Christopher J. L. Newth,Trung C. Nguyen,Akira Nishisaki,Mark E. Nunnally,Margaret M. Parker,Raina Paul,Adrienne G. Randolph,Suchitra Ranjit,Lewis H. Romer,Halden F. Scott,Lyvonne N Tume,Judy T. Verger,Judy T. Verger,Eric A. Williams,Joshua Wolf,Hector R. Wong,Jerry J. Zimmerman,Niranjan Kissoon,Pierre Tissieres,Pierre Tissieres +53 more
TL;DR: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations.
Journal ArticleDOI
Hypoalbuminemia: Pathogenesis and Clinical Significance.
TL;DR: Management of hypoalbuminaemia should be based on correcting the causes of ongoing inflammation rather than infusion of albumin, and increasing or decreasing serum albumin levels are adequate indicators, respectively, of improvement or deterioration of the clinical state.
Journal ArticleDOI
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Scott L. Weiss,Mark J. Peters,Waleed Alhazzani,Michael S. D. Agus,Heidi R. Flori,David Inwald,Simon Nadel,Luregn J. Schlapbach,Robert C. Tasker,Andrew C. Argent,Joe Brierley,Joseph Carcillo,Enitan D. Carrol,Christopher L. Carroll,Ira M. Cheifetz,Karen Choong,Jeffry J. Cies,Andrea T. Cruz,Daniele De Luca,Daniele De Luca,Akash Deep,Saul N. Faust,Claudio Flauzino De Oliveira,Mark W. Hall,Paul Ishimine,Etienne Javouhey,Koen F. M. Joosten,Poonam Joshi,Oliver Karam,Martin C. J. Kneyber,Joris Lemson,Graeme MacLaren,Graeme MacLaren,Nilesh M. Mehta,Morten Hylander Møller,Christopher J. L. Newth,Trung C. Nguyen,Akira Nishisaki,Mark E. Nunnally,Margaret M. Parker,Raina Paul,Adrienne G. Randolph,Suchitra Ranjit,Lewis H. Romer,Halden F. Scott,Lyvonne N Tume,Judy T. Verger,Judy T. Verger,Eric A. Williams,Joshua Wolf,Hector R. Wong,Jerry J. Zimmerman,Niranjan Kissoon,Pierre Tissieres,Pierre Tissieres +54 more
TL;DR: A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations.
Journal ArticleDOI
Neonatal Acute Kidney Injury.
David T. Selewski,Jennifer R. Charlton,Jennifer G. Jetton,Ronnie Guillet,Maroun J. Mhanna,David J. Askenazi,Alison L. Kent +6 more
TL;DR: This review highlights the deficits in the understanding of neonatal AKI that require further investigation and discusses the need for long-term follow-up of neonates with AKI to identify those children who will go on to develop chronic kidney disease.
Journal ArticleDOI
ICU-acquired weakness
TL;DR: Results of studies investigating the impact of early mobilization, neuromuscular electrical stimulation and of pharmacological interventions were inconsistent, with recent systematic reviews/meta-analyses revealing no or only low-quality evidence for benefit.
References
More filters
WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age - Methods and development
Mercedes de Onis,Adelheid W. Onyango,Elaine Borghi,Amani Siyam,Alain Pinol,Cutberto Garza,Jose Martines,Reynaldo Martorell,Cesar G. Victora,Maharaj K. Bhan,Cora L. Araújo,Anna Lartey,William B. Owusu,Nita Bhandari,Kaare R. Norum,Gunn-Elin A. Bjoerneboe,Ali J. Mohamed,Kathryn G. Dewey,Krishna Belbase,Maureen Black,Wm. Cameron Chumlea,Tim Cole,Edward Frongillo,Laurence Grummer-Strawn,Roger Shrimpton,Jan Van den Broeck,Huiqi Pan,Robert Rigby,Mikis Stasinopoulos,Stef van Buuren,Elaine Albernaz,Elaine Tomasi,Rita de Cássia Fossati da Silveira,Gisele Nader,Isabella Sagoe-Moses,Veronica Gomez,Charles Sagoe-Moses,Sunita Taneja,Temsunaro Rongsen,Jyotsna Chetia,Pooja Sharma,Rajiv Bahl,Anne Baerug,Elisabeth Tufte,Karin Rudvin,Hilde Nysaether,Deena Alasfoor,Nitya S. Prakash,Ruth M. Mabry,Hanadi J. Al Rajab,Sahar A. Helmi,Laurie A. Nommsen-Rivers,Roberta J. Cohen,M. Jane Heinig +53 more
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
1. Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), Supported by the European Society of Paediatric Research (ESPR).
TL;DR: These Guidelines for Paediatric Parenteral Nutrition have been developed as a mutual project of the European Society for paediatric Gastroenterology, Hepatology and Nutrition and the European society for Clinical Nutrition and Metabolism.
Journal ArticleDOI
Autophagy Is Required to Maintain Muscle Mass
Eva Masiero,Lisa Agatea,Cristina Mammucari,Bert Blaauw,Emanuele Loro,Masaaki Komatsu,Daniel Metzger,Carlo Reggiani,Stefano Schiaffino,Marco Sandri +9 more
TL;DR: It is reported that muscle-specific deletion of a crucial autophagy gene, Atg7, resulted in profound muscle atrophy and age-dependent decrease in force and the results suggest that inhibition/alteration of Autophagy can contribute to myofiber degeneration and weakness in muscle disorders characterized by accumulation of abnormal mitochondria and inclusions.
Journal ArticleDOI
Inflammatory bowel disease in children and adolescents: Recommendations for diagnosis - The Porto criteria
Johanna C. Escher,J. A. Dias,K. Bochenek,Stephan Buderus,M.B. de Mesquita,Yoram Bujanover,Hans A. Büller,Sonny K. F. Chong,Salvatore Cucchiara,J. Fell,J. Henker,Hans Hildebrand,Jean-Pierre Hugot,U. Jedynak,H. R. Jenkins,Sanja Kolaček,S. Koletzko,I. Lazowska,Arie Levine,Paolo Lionetti,J. Maly,Scott Montgomery,S H Murch,M.S. Murphy,Anders Paerregaard,Bhupinder Sandhu,A.. Sawczenko +26 more
TL;DR: The Porto diagnostic criteria presented here provide the tool that is needed for uniformity in the work-up and criteria used for diagnosis of pediatric inflammatory bowel disease.
Related Papers (5)
Early versus Late Parenteral Nutrition in Critically Ill Adults
Michael P Casaer,Dieter Mesotten,Greet Hermans,Pieter Wouters,Miet Schetz,Geert Meyfroidt,Sophie Van Cromphaut,Catherine Ingels,Philippe Meersseman,Jan Muller,Dirk Vlasselaers,Yves Debaveye,Lars Desmet,Jasperina Dubois,Aimé Van Assche,Simon Vanderheyden,Alexander Wilmer,Greet Van den Berghe +17 more
A.S.P.E.N. Clinical Guidelines: Nutrition Support of the Critically Ill Child
Nilesh M. Mehta,Charlene Compher +1 more