Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD
Federico Lavorini,Antoine Magnan,Antoine Magnan,Jean Christophe Dubus,Thomas Voshaar,Lorenzo Corbetta,Mariëlle E.A.C. Broeders,Richard Dekhuijzen,Joaquín Sanchis,José Luis Viejo,Peter J. Barnes,Christopher Corrigan,Mark L Levy,Graham K. Crompton +13 more
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TLDR
It is demonstrated that incorrect DPI technique with established DPIs is common among patients with asthma and COPD, and suggests that poor inhalation technique has detrimental consequences for clinical efficacy.About:
This article is published in Respiratory Medicine.The article was published on 2008-04-01 and is currently open access. It has received 542 citations till now. The article focuses on the topics: Dry-powder inhaler & Inhaler.read more
Citations
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Journal ArticleDOI
Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data.
Kaveh Ahookhosh,Maysam Saidi,Habib Aminfar,Mousa Mohammadpourfard,Mousa Mohammadpourfard,Hamed Hamishehkar,Shadi Yaqoubi +6 more
TL;DR: The validated CFD model provided an opportunity to cover the limitations of the previous experimental investigation on aerosol deposition of commercial inhalers and became an efficient method for further studies.
Journal ArticleDOI
Recent educational interventions for improvement of asthma medication adherence
Malin Axelsson,Jan Lötvall +1 more
TL;DR: It is proposed that educational adherence support should be a collaborative effort between the patient and the health-care professional based on each individual patient's needs and patient factors, including elements such as personality traits.
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The influence of type of inhalation device on adherence of COPD patients to inhaled medication
Kirsten Koehorst-ter Huurne,Kris L. L. Movig,Paul van der Valk,Job van der Palen,Marjolein Brusse-Keizer +4 more
TL;DR: In COPD, adherence to inhalation medication is device-related and overuse was most pronounced for devices without a dose counter, devices with the ability to load a dosage without actual inhalation, or devices lacking feedback of correct inhalation.
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Global burden of medication non-adherence in chronic obstructive pulmonary disease (COPD) and asthma: a narrative review of the clinical and economic case for smart inhalers.
Evalyne M. Jansen,Susanne J. van de Hei,Susanne J. van de Hei,Boudewijn J H Dierick,Boudewijn J H Dierick,Huib A. M. Kerstjens,Huib A. M. Kerstjens,Janwillem W. H. Kocks,Job F M van Boven,Job F M van Boven +9 more
TL;DR: It is likely that smart inhalers are particularly cost-effective in specific asthma and chronic obstructive pulmonary disease subgroups, including patients with asthma eligible for additional GINA-5 therapy (oral corticosteroids or biologics), patients with severe asthma in Gina-5, and patients with short-acting beta2 agonists overuse.
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A review of the value of innovation in inhalers for COPD and asthma
Johann Christian Virchow,Cezmi A. Akdis,Josep Darbà,Richard Dekhuijzen,Sylvia Hartl,Gisela Kobelt,Albert Roger,Steven Simoens,Mondher Toumi,Ben Woodhouse,Adam Plich,Saku Torvinen +11 more
TL;DR: There remains a substantial unmet need for inhaler technology and that innovation in inhaler devices can provide real-world health benefits to patients, and it is recommended that these innovations should be supported by healthcare systems through appropriate pricing and reimbursement mechanisms.
References
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Universities and tobacco money.
TL;DR: Nottingham University's establishment of an international centre for corporate social responsibility, with initial funding of £3.8m provided by British American Tobacco, joins a long list of universities that have accepted funding from the tobacco industry.
Journal ArticleDOI
Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability
Violaine Giraud,Nicolas Roche +1 more
TL;DR: Misuse of pressurized metered-dose inhalers, which is mainly due to poor coordination, is frequent and associated with poorer asthma control in inhaled corticosteroid-treated asthmatics, highlighting the importance of evaluating inhalation technique and providing appropriate education in all patients.
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Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size.
TL;DR: Regional targeting of inhaled beta2-agonist to the proximal airways is more important than distal alveolar deposition for bronchodilation and can appreciably enhance inhaled drug therapy and may have implications for developing future inhaled treatments.
Journal ArticleDOI
Inhaled corticosteroids for asthma therapy: patient compliance, devices, and inhalation technique.
TL;DR: It is demonstrated that multiple factors may come between a prescription of an inhaled corticosteroid and the arrival of that medicine at its target organ, the lung.
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Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care.
Mathieu Molimard,Chantal Raherison,Séverine Lignot,F. Depont,Abdelilah Abouelfath,Nicholas Moore +5 more
TL;DR: The results suggest that there are differences in the handling of inhaler devices in real life in primary care that are not taken into account in controlled studies.
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