Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
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TLDR
It is reported that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.Abstract:
In animal models, prenatal and postnatal stress is associated with elevated hypothalamic–pituitary axis (HPA) reactivity mediated via altered glucocorticoid receptor (GR) gene expression. Postnatal tactile stimulation is associated with reduced HPA reactivity mediated via increased GR gene expression. In this first study in humans to examine the joint effects of prenatal and postnatal environmental exposures, we report that GR gene (NR3C1) 1-F promoter methylation in infants is elevated in the presence of increased maternal postnatal depression following low prenatal depression, and that this effect is reversed by self-reported stroking of the infants by their mothers over the first weeks of life.read more
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Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis.
TL;DR: The proposed association between a specific CpG site located at the NR3C1 promoter and prenatal stress is supported, and several confounders, such as gender, methylation at other glucocorticoid-related genes, and adjustment for pharmacological treatments during pregnancy, should be taken into account in further studies.
Journal ArticleDOI
Mental health of pregnant women during the COVID-19 pandemic: A longitudinal study.
Hernán López-Morales,Hernán López-Morales,Macarena Verónica del Valle,Lorena Canet-Juric,María Laura Andrés,Juan Ignacio Galli,Fernando Martín Poó,Sebastián Urquijo +7 more
TL;DR: PregnantWomen showed a more pronounced increase in depression, anxiety and negative affect than the non-pregnant women did, and aMore pronounced decrease in positive affect, which is important for institutions dedicated to perinatal health care to count on empirical information to optimize the provision of their services.
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Prenatal stress and epigenetics
Lei Cao-Lei,S. R. de Rooij,Suzanne King,Stephen G. Matthews,Gerlinde A. S. Metz,Tessa J. Roseboom,Moshe Szyf +6 more
TL;DR: Evidence from animal and human prenatal research supporting the view that prenatal stress could lead to lasting, broad and functionally organized signatures in DNA methylation which, in turn, could mediate exposure-phenotype associations is outlined.
Journal ArticleDOI
Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
TL;DR: The epigenetic signatures of postnatal adversity such as childhood abuse or maltreatment and later-life psychopathology in human and animal models of early life stress are analyzed to provide current evidence demonstrating changes in the epigenetic signature of candidate gene(s) in response to early environmental adversity.
Journal ArticleDOI
A review of DNA methylation in depression.
TL;DR: Although evidence provided insights to epigenetic processes in depression, the findings were inconsistent and longitudinal studies in animal models and in patients with depression are needed to further investigate the diagnostic predictive value of DNA methylation reliably.
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