Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review.
TLDR
Great consistency was found among studies investigating early-life adversity and the effect of parental stress, even if the precise phenotype and measures of social environment adversity varied among studies.About:
This article is published in Biological Psychiatry.The article was published on 2016-01-15 and is currently open access. It has received 552 citations till now. The article focuses on the topics: DNA methylation & Epigenetics.read more
Citations
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Suicide and suicidal behaviour
Gustavo Turecki,David A. Brent +1 more
TL;DR: Improved recognition and understanding of clinical, psychological, sociological, and biological factors might help the detection of high-risk individuals and assist in treatment selection.
Journal ArticleDOI
Racism and Health: Evidence and Needed Research.
TL;DR: An overview of the evidence linking the primary domains of racism-structural racism, cultural racism, and individual-level discrimination-to mental and physical health outcomes is provided.
Journal ArticleDOI
Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation
Rachel Yehuda,Rachel Yehuda,Nikolaos P. Daskalakis,Nikolaos P. Daskalakis,Linda M. Bierer,Linda M. Bierer,Heather N. Bader,Heather N. Bader,Torsten Klengel,Torsten Klengel,Florian Holsboer,Elisabeth B. Binder,Elisabeth B. Binder +12 more
TL;DR: This is the first demonstration of an association of preconception parental trauma with epigenetic alterations that is evident in both exposed parent and offspring, providing potential insight into how severe psychophysiological trauma can have intergenerational effects.
Journal ArticleDOI
Suicide and suicide risk
Gustavo Turecki,David A. Brent,David Gunnell,David Gunnell,Rory C. O'Connor,Maria A. Oquendo,Jane Pirkis,Barbara Stanley +7 more
TL;DR: The global burden of suicide and suicidal behaviours is discussed, and an overview of the current understanding of the mechanisms of suicide is provided, including risk factors for suicidal ideation and the transition from ideation to suicide attempt.
Gender and mental health.
Sarah Rosenfield,Dawne M. Mouzon +1 more
TL;DR: Men and women experience different kinds of mental health problems as mentioned in this paper, while women exceed men in internalizing disorders such as depression and anxiety, men exhibit more externalizing disorders, such as substance abuse and antisocial behavior, which are problematic for others.
References
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.
Marianne Frommer,Louise E. McDonald,Douglas Spencer Millar,Christina M. Collis,Fujiko Watt,Geoffrey W. Grigg,Peter L. Molloy,Cheryl L. Paul +7 more
TL;DR: A genomic sequencing method is reported that provides positive identification of 5-methylcytosine residues and yields strand-specific sequences of individual molecules in genomic DNA, which suggests that the high methylation level of single-copy sequences in sperm may be locally modulated by binding of protein factors in germ-line cells.
Journal ArticleDOI
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
Journal ArticleDOI
Burden and consequences of child maltreatment in high-income countries
Ruth Gilbert,Cathy Spatz Widom,Kevin D. Browne,Kevin D. Browne,David M. Fergusson,Elspeth Webb,Staffan Janson +6 more
TL;DR: For example, this article found that exposure to multiple types and repeated episodes of maltreatment is associated with increased risks of severe maltreatment and psychological consequences, which has longlasting effects on mental health, drug and alcohol misuse (especially in girls), risky sexual behaviour, obesity, and criminal behaviour.
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