Effects of Reagent and Enzymatically Generated Hypochlorite on Physicochemical and Metabolic Properties of High Density Lipoproteins
Ute Panzenboeck,Sabine Raitmayer,Helga Reicher,Helmut Lindner,Otto Glatter,Ernst Malle,Wolfgang Sattler +6 more
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TLDR
Results demonstrate that the modification of HDL3 by hypochlorite transformed an antiatherogenic lipop Protein particle into a modified lipoprotein with characteristics similar to lipoproteins commonly thought to initiate foam cell formation in vivo.About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-11-21 and is currently open access. It has received 109 citations till now. The article focuses on the topics: Lipoprotein particle & Reagent.read more
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Journal ArticleDOI
Oxysterols: modulators of cholesterol metabolism and other processes.
TL;DR: This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.
Journal ArticleDOI
Myeloperoxidase and Cardiovascular Disease
TL;DR: Myeloperoxidase is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species that represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.
Journal ArticleDOI
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
Lemin Zheng,Benedicta Nagella Nukuna,Marie Luise Brennan,Mingjiang Sun,Marlene Goormastic,Megan Settle,Dave Schmitt,Xiaoming Fu,Leonor Thomson,Paul L. Fox,Harry Ischiropoulos,Jonathan D. Smith,Michael Kinter,Stanley L. Hazen +13 more
TL;DR: The present results provide the first direct evidence for apoA-I as a selective target forMPO-catalyzed oxidative modification in human atheroma and suggest a potential mechanism for MPO-dependent generation of a proatherogenic dysfunctional form of HDL in vivo.
Journal ArticleDOI
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport
Constanze Bergt,Subramaniam Pennathur,Xiaoyun Fu,Jaeman Byun,Kevin D. O'Brien,Thomas O. McDonald,Pragya Singh,Gattadahalli M. Anantharamaiah,Alan Chait,John D. Brunzell,Randolph L. Geary,John F. Oram,Jay W. Heinecke +12 more
TL;DR: Levels of 3-chlorotyrosine were elevated in HDL isolated from the blood of humans with established coronary artery disease, suggesting that circulating levels of oxidized HDL represent a unique marker for clinically significant atherosclerosis.
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Immunohistochemical evidence for the myeloperoxidase/H2O2/halide system in human atherosclerotic lesions. Colocalization of myeloperoxidase and hypochlorite-modified proteins
Ernst Malle,Georg Waeg,Renate Schreiber,Elisabeth F. Gröne,Wolfgang Sattler,Hermann Josef Gröne +5 more
TL;DR: The colocalization of immunoreactive MPO and HOCl-modified-epitopes in serial sections of human atheroma, fibroatheroma (type V) and complicated (type VI) lesions provides further convincing evidence for MPO/H2O2/halide system-mediated oxidation of (lipo)proteins under in vivo conditions.
References
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Analysis of Macromolecular Polydispersity in Intensity Correlation Spectroscopy: The Method of Cumulants
TL;DR: The first order electric field correlation function of laser light scattered by polydisperse solutions of macromolecules can be written as a sum or distribution of exponentials, with decay rates proportional to the diffusion coefficients of the solute molecules as discussed by the authors.
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Molecular physiology of reverse cholesterol transport.
TL;DR: The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated, and RCT can now be understood in molecular terms.
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Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
TL;DR: Findings identify myeloperoxidase as a component of human vascular lesions and suggest that this heme protein can generate reactive species that damage lipids and proteins may contribute to atherogenesis by catalyzing oxidative reactions in the vascular wall.
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The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.
Jere P. Segrest,Martin K. Jones,H De Loof,Christie G. Brouillette,Y. V. Venkatachalapathi,Gattadahalli M. Anantharamaiah +5 more
TL;DR: It is of particular interest, therefore, that all of the exchangeable apolipoproteins except apoA-II and C-I, contain amphipathic helixes of class G*.
Related Papers (5)
3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
Stanley L. Hazen,Jay W. Heinecke +1 more