Journal ArticleDOI
Eight-plasmid system for rapid generation of influenza virus vaccines.
Erich Hoffmann,Scott Krauss,Daniel R. Perez,Richard J. Webby,Robert G. Webster,Robert G. Webster +5 more
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TLDR
These findings demonstrate that the eight-plasmid system allows the rapid and reproducible generation of reassortant influenza A viruses for use in the manufacture of vaccines.About:
This article is published in Vaccine.The article was published on 2002-08-19. It has received 443 citations till now. The article focuses on the topics: Influenza A virus & Orthomyxoviridae.read more
Citations
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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
Paul G. Thomas,Pradyot Dash,Jerry R. Aldridge,Ali H. Ellebedy,Cory Reynolds,Amy J. Funk,William J. Martin,Mohamed Lamkanfi,Richard J. Webby,Kelli L. Boyd,Peter C. Doherty,Peter C. Doherty,Thirumala-Devi Kanneganti +12 more
TL;DR: It is demonstrated that Nlrp3 and Casp1(-/-) mice were more susceptible than wild-type mice after infection with a pathogenic influenza A virus, and cryopyrin and caspase-1 are central to both innate immunity and to moderating lung pathology in influenza pneumonia.
Journal ArticleDOI
Are we ready for pandemic influenza
TL;DR: Here, progress to date in preparedness for an influenza pandemic is considered and what remains to be done is reviewed, with prioritizing the remaining needs and exploring the reasons for the current lack of preparedness.
Journal ArticleDOI
Virus glycosylation: role in virulence and immune interactions
TL;DR: This review focuses on recent findings on the importance of glycosylation to viral virulence and immune evasion for several prominent human pathogens.
Journal ArticleDOI
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
Eric J. Yager,Mushtaq Ahmed,Kathleen G. Lanzer,Troy D. Randall,David L. Woodland,Marcia A. Blackman +5 more
TL;DR: It is shown in a mouse infection model that naturally occurring contraction of the naive T cell repertoire can result in impaired CD8 T cell responses to known immunodominant epitopes and decline in heterosubtypic immunity, which has important implications for the design of vaccine strategies for the elderly.
Journal ArticleDOI
Evolution of H5N1 avian influenza viruses in Asia
Jean Thierry Aubin,Saliha Azebi,Amanda Balish,Jill Banks,Niranjan Bhat,Rick A. Bright,Ian Brown,Philippe Buchy,Ana Maria Burguiere,Hua Ian Chen,Peter K.C. Cheng,Nancy J. Cox,Alice Crosier,Aaron Curns,Frédérique Cuvelier,Guohua Deng,Julia Desheva,Stéphanie Desvaux,Nguyen Hong Diep,Ruben O. Donis,Ruben O. Donis,A. R. Douglas,Scott F. Dowell,Nguyen Tien Dung,Lindsay Edwards,Keiji Fukuda,Rebecca Garten,Elena A. Govorkova,Victoria Gregory,Alan W. Hampson,Nguyen Thi Hong Hanh,Scott A. Harper,A. Hay,Erich Hoffmann,Diane J. Hulse,Masaki Imai,Shigeyuki Itamura,Samadhan Jadhao,Patricia Jeannin,Chun Kang,Jackie Katz,Jae Hong Kim,Alexander Klimov,Yong Kuk Kwon,Chang-Won Lee,Phuong Song Lien,Yanbing Li,Wilina Lim,Yi Pu Lin,Stephen Lindstom,La Morris Loftin,Jan Mabry,Le Quynh Mai,Taronna R. Maines,Jean Claude Manuguerra,Masaji Mase,Yumi Matsuoka,Margaret McCarron,Marie-Jo Medina,Doan Nguyen,Ai Ninomiya,Masatsugu Obuchi,Takato Odagiri,Malik Peiris,Michael L. Perdue,Jean Marc Reynes,James Robertson,Claudine Rousseaux,Takehiko Saito,Somchai Sangkitporn,Michael W. Shaw,James Mark Simmerman,Marek J. Slomka,Catherine K. Smith,San Sorn,Erica Spackman,Klaus Stöhr,David L. Suarez,Haan Woo Sung,David E. Swayne,Maryse Tardy-Panit,Masato Tashiro,Pranee Thawatsupha,Terrence M. Tumpey,Timothy M. Uyeki,Phan Van Tu,Sylvie van der Werf,Sirenda Vong,Richard J. Webby,Robert G. Webster,John Wood,Xiyan Xu,Guan Yi,Wenging Zhang +93 more
TL;DR: Human infections were from a virus clade undergoing antigenic drift that showed resistance to adamantanes but sensitivity to neuraminidase inhibitors.
References
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Journal ArticleDOI
Universal primer set for the full-length amplification of all influenza A viruses.
TL;DR: The resultant primer set is suitable for all influenza A viruses to generate full-length cDNAs, to subtype viruses, to sequence their DNA, and to construct expression plasmids for reverse genetics systems.
Journal ArticleDOI
A DNA transfection system for generation of influenza A virus from eight plasmids
TL;DR: An eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA facilitates the design and recovery of both recombinant and reassortant influenza A viruses, and may also be applicable to the recovery of other RNA viruses entirely from cloning cDNA.
Journal ArticleDOI
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
E.C.J. Claas,Albert D. M. E. Osterhaus,Ruud van Beek,Jan C. de Jong,Guus F. Rimmelzwaan,Dennis A. Senne,Scott Krauss,Kennedy F. Shortridge,Robert G. Webster +8 more
TL;DR: The results suggest transmission of the virus from infected chickens to the child without another intermediate mammalian host acting as a "mixing vessel" illustrates the importance of intensive global influenza surveillance.
Journal ArticleDOI
Generation of influenza A viruses entirely from cloned cDNAs
Gabriele Neumann,Tokiko Watanabe,Hiroshi Ito,Shinji Watanabe,Hideo Goto,Peng Gao,Mark A. Hughes,Daniel R. Perez,Ruben O. Donis,Erich Hoffmann,Gerd Hobom,Yoshihiro Kawaoka +11 more
TL;DR: A new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs is described, which should be useful in viral mutagenesis studies and in the production of vaccines and gene therapy vectors.
Journal ArticleDOI
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.
Kanta Subbarao,Alexander Klimov,Alexander Klimov,Alexander Klimov,Jacqueline M. Katz,Jacqueline M. Katz,Jacqueline M. Katz,Helen L. Regnery,Helen L. Regnery,Helen L. Regnery,Wilina Lim,Wilina Lim,Wilina Lim,Henrietta Hall,Henrietta Hall,Henrietta Hall,Michael L. Perdue,Michael L. Perdue,Michael L. Perdue,David E. Swayne,David E. Swayne,David E. Swayne,Catherine A. Bender,Catherine A. Bender,Catherine A. Bender,Jing Huang,Jing Huang,Jing Huang,Mark L. Hemphill,Mark L. Hemphill,Mark L. Hemphill,Thomas Rowe,Thomas Rowe,Thomas Rowe,Michael W. Shaw,Michael W. Shaw,Michael W. Shaw,Xiyan Xu,Xiyan Xu,Xiyan Xu,Keiji Fukuda,Keiji Fukuda,Keiji Fukuda,Nancy Cox,Nancy Cox,Nancy Cox +45 more
TL;DR: An avian H5N1 influenza A virus was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza, causing 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens.
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