Evolution of H5N1 avian influenza viruses in Asia
Jean Thierry Aubin,Saliha Azebi,Amanda Balish,Jill Banks,Niranjan Bhat,Rick A. Bright,Ian Brown,Philippe Buchy,Ana Maria Burguiere,Hua Ian Chen,Peter K.C. Cheng,Nancy J. Cox,Alice Crosier,Aaron Curns,Frédérique Cuvelier,Guohua Deng,Julia Desheva,Stéphanie Desvaux,Nguyen Hong Diep,Ruben O. Donis,Ruben O. Donis,A. R. Douglas,Scott F. Dowell,Nguyen Tien Dung,Lindsay Edwards,Keiji Fukuda,Rebecca Garten,Elena A. Govorkova,Victoria Gregory,Alan W. Hampson,Nguyen Thi Hong Hanh,Scott A. Harper,A. Hay,Erich Hoffmann,Diane J. Hulse,Masaki Imai,Shigeyuki Itamura,Samadhan Jadhao,Patricia Jeannin,Chun Kang,Jackie Katz,Jae Hong Kim,Alexander Klimov,Yong Kuk Kwon,Chang-Won Lee,Phuong Song Lien,Yanbing Li,Wilina Lim,Yi Pu Lin,Stephen Lindstom,La Morris Loftin,Jan Mabry,Le Quynh Mai,Taronna R. Maines,Jean Claude Manuguerra,Masaji Mase,Yumi Matsuoka,Margaret McCarron,Marie-Jo Medina,Doan Nguyen,Ai Ninomiya,Masatsugu Obuchi,Takato Odagiri,Malik Peiris,Michael L. Perdue,Jean Marc Reynes,James Robertson,Claudine Rousseaux,Takehiko Saito,Somchai Sangkitporn,Michael W. Shaw,James Mark Simmerman,Marek J. Slomka,Catherine K. Smith,San Sorn,Erica Spackman,Klaus Stöhr,David L. Suarez,Haan Woo Sung,David E. Swayne,Maryse Tardy-Panit,Masato Tashiro,Pranee Thawatsupha,Terrence M. Tumpey,Timothy M. Uyeki,Phan Van Tu,Sylvie van der Werf,Sirenda Vong,Richard J. Webby,Robert G. Webster,John Wood,Xiyan Xu,Guan Yi,Wenging Zhang +93 more
TLDR
Human infections were from a virus clade undergoing antigenic drift that showed resistance to adamantanes but sensitivity to neuraminidase inhibitors.Abstract:
Human infections were from a virus clade undergoing antigenic drift that showed resistance to adamantanes but sensitivity to neuraminidase inhibitors.read more
Citations
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Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses
Jianhua Sui,William C. Hwang,Sandra Elizabeth Pérez,Ge Wei,Daniel Aird,Li-Mei Chen,Eugenio Santelli,Boguslaw Stec,Greg Cadwell,Maryam Ali,Hongquan Wan,Akikazu Murakami,Anuradha Yammanuru,Thomas Han,Nancy J. Cox,Laurie A. Bankston,Ruben O. Donis,Robert C. Liddington,Wayne A. Marasco +18 more
TL;DR: The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion, and suggests that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.
Journal ArticleDOI
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
James Stevens,Ola Blixt,Terrence M. Tumpey,Jeffery K. Taubenberger,James C. Paulson,Ian A. Wilson +5 more
TL;DR: The hemagglutinin structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA, which suggests a path for this H 5N1 virus to gain a foothold in the human population.
Journal ArticleDOI
Avian Influenza Virus (H5N1): a Threat to Human Health
TL;DR: The ecology and evolution of highly pathogenic avian influenza H5N1 viruses are reviewed, the pandemic risk is assessed, and aspects of human H 5N1 disease are addressed in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management.
Journal ArticleDOI
Innate immunity to influenza virus infection.
Akiko Iwasaki,Padmini S. Pillai +1 more
TL;DR: Whether the outcome of innate sensor stimulation promotes antiviral resistance or disease tolerance, and proposed rational treatment strategies for the acute respiratory disease that is caused by influenza virus infection are considered.
Journal ArticleDOI
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
Rupert J. Russell,Lesley F. Haire,D.J. Stevens,Patrick J. Collins,Yi Pu Lin,G. Michael Blackburn,Alan Hay,Steven J. Gamblin,John J. Skehel +8 more
TL;DR: It may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs, according to X-ray crystallography, which shows that these two groups of neuraminidases are structurally distinct.
References
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Journal ArticleDOI
A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
Journal ArticleDOI
A DNA transfection system for generation of influenza A virus from eight plasmids
TL;DR: An eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA facilitates the design and recovery of both recombinant and reassortant influenza A viruses, and may also be applicable to the recovery of other RNA viruses entirely from cloning cDNA.
Journal ArticleDOI
Generation of influenza A viruses entirely from cloned cDNAs
Gabriele Neumann,Tokiko Watanabe,Hiroshi Ito,Shinji Watanabe,Hideo Goto,Peng Gao,Mark A. Hughes,Daniel R. Perez,Ruben O. Donis,Erich Hoffmann,Gerd Hobom,Yoshihiro Kawaoka +11 more
TL;DR: A new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs is described, which should be useful in viral mutagenesis studies and in the production of vaccines and gene therapy vectors.
Journal ArticleDOI
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
K. S. Li,Yi Guan,Yi Guan,Jianbo Wang,Jianbo Wang,Gavin J. D. Smith,Gavin J. D. Smith,K. M. Xu,K. M. Xu,Lian Duan,Lian Duan,A. P. Rahardjo,Pilaipan Puthavathana,Chantanee Buranathai,Toan D. Nguyen,A. T. S. Estoepangestie,A. Chaisingh,Prasert Auewarakul,H. T. Long,N. T. H. Hanh,Richard J. Webby,Leo L.M. Poon,Honglin Chen,Honglin Chen,Kennedy F. Shortridge,Kennedy F. Shortridge,Kwok-Yung Yuen,Robert G. Webster,Robert G. Webster,Joseph S. M. Peiris,Joseph S. M. Peiris +30 more
TL;DR: The findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia.
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Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
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