Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.
Xiao-Qing Liu,Yun Zhao,Jiangang Gao,Basil S. Pawlyk,Barry Starcher,Jeffrey A. Spencer,Hiromi Yanagisawa,J. Zuo,Tiansen Li +8 more
TLDR
It is shown that mice lacking the protein lysyl oxidase–like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation.Abstract:
Elastic fibers are components of the extracellular matrix and confer resilience1. Once laid down, they are thought to remain stable2, except in the uterine tract where cycles of active remodeling occur3. Loss of elastic fibers underlies connective tissue aging and important diseases including emphysema4,5,6,7. Failure to maintain elastic fibers is explained by a theory of antielastase-elastase imbalance8, but little is known about the role of renewal. Here we show that mice lacking the protein lysyl oxidase–like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation. Distinct from the prototypic lysyl oxidase (LOX), LOXL1 localizes specifically to sites of elastogenesis and interacts with fibulin-5. Thus elastin polymer deposition is a crucial aspect of elastic fiber maintenance and is dependent on LOXL1, which serves both as a cross-linking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin.read more
Citations
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Phenotypic and functional characterization of primary murine endothelial cells after in vivo irradiation
TL;DR: A novel method for the isolation of viable primary ECs at high purity from non-proliferating (heart from young and old mice), proliferating benign (repair blastema) and malignant (tumor) tissues at high yields is established and it is suggested that increased expression of surface molecules on ECs in proliferating tissues contributes to a loss of EC function that might be responsible for a chaotic tumor vasculature.
Book ChapterDOI
Biofortification of Rice (Oryza sativa L.)
TL;DR: Different techniques of rice bio-fortification, as well as their effects have been explored in this chapter as discussed by the authors , which refers to developing a micronutrient-rich diet by utilising traditional breeding practices and sophisticated biotechnological tools.
Journal ArticleDOI
FBN2 Silencing Recapitulates Hypoxic Conditions and Induces Elastic Fiber Impairment in Human Dermal Fibroblasts
Jérémy Boizot,Mélaine Minville-Walz,Dieter P. Reinhardt,Marielle Bouschbacher,Pascal Sommer,Dominique Sigaudo-Roussel,Romain Debret +6 more
TL;DR: The involvement of FBN2 in regulatingElastin deposition in adult skin models is demonstrated and the specific impact of hypoxia on the elastin network without consequences on collagen and fibronectin networks is described.
Lisil-oxidasa (LOX) y proteínas tipo LOX: rol de amino-oxidasas, propiedades moleculares y catalíticas* Lysyl oxidase (LOX) and LOX-like proteins: role of amino-oxidases, molecular and catalytic properties Lisil-oxidase (LOX) e proteinas tipo LOX: papel da amino-oxidases, propriedades moleculares e catalíticas
TL;DR: In this article, it was shown that Las amino-oxidasas pertenecen a two grupos de proteinas: flavoenzimas and quinoenzimas.
Book ChapterDOI
Genetics of Exfoliation Syndrome in Asians
TL;DR: Evidence is provided regarding the well-studied genetic, nongenetic, and other associated risk factor-based argument which enriches the understanding of this complex inherited disorder for future research.
References
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Journal ArticleDOI
Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice
TL;DR: Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocyte chemoattractant protein-1 showed accumulation of alveolar macrophages but did not develop air space enlargement, indicating that macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.
Journal ArticleDOI
Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
TL;DR: Although the three‐dimensional structure of LO has yet to be determined, the present treatise offers hypotheses based upon its primary sequence, which may underlie the prominent electrostatic component of its unusual substrate specificity as well as the catalysis‐suppressing function of the propeptide domain of prolysyl oxidase.
Journal ArticleDOI
Fibulin-5/DANCE is essential for elastogenesis in vivo
Tomoyuki Nakamura,Pilar Ruiz Lozano,Yasuhiro Ikeda,Yoshitaka Iwanaga,Aleksander Hinek,Susumu Minamisawa,Ching-Feng Cheng,Kazuhiro Kobuke,Nancy D. Dalton,Yoshikazu Takada,Kei Tashiro,John Ross,Tasuku Honjo,Kenneth R. Chien +13 more
TL;DR: It is reported that fibulin-5 (also known as DANCE), a recently discovered integrin ligand, is an essential determinant of elastic fibre organization and may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibre in the skin, lung and vasculature.
Journal ArticleDOI
Effect of vaginal delivery on the pelvic floor: A 5‐year follow‐up
TL;DR: Evidence is provided for the hypothesis that pudendal neuropathy due to vaginal delivery persists and may worsen with time and for the effect of childbirth on the pelvic floor striated sphincter musculature.
Journal ArticleDOI
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo
Hiromi Yanagisawa,Elaine C. Davis,Barry Starcher,Takashi Ouchi,Masashi Yanagisawa,James A. Richardson,Eric N. Olson +6 more
TL;DR: Fibulin-5-/- mice develop marked elastinopathy owing to the disorganization of elastic fibres, with resulting loose skin, vascular abnormalities and emphysematous lung, which resembles the cutis laxa syndrome in humans.
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Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
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