Endocrine Disrupting Effects of Triclosan on the Placenta in Pregnant Rats
Reads0
Chats0
TLDR
It is demonstrated that the placenta was a target tissue of TCS and that TCS induced inhibition of circulating steroid hormone production might be related to the altered expression of hormone metabolism enzyme genes in thePlacenta.Abstract:
Triclosan (TCS) is a broad-spectrum antimicrobial agent that is frequently used in pharmaceuticals and personal care products. Reports have shown that TCS is a potential endocrine disruptor; however, the potential effects of TCS on placental endocrine function are unclear. The aim of this study was to investigate the endocrine disrupting effects of TCS on the placenta in pregnant rats. Pregnant rats from gestational day (GD) 6 to GD 20 were treated with 0, 30, 100, 300 and 600 mg/kg/d TCS followed by analysis of various biochemical parameters. Of the seven tissues examined, the greatest bioaccumulation of TCS was observed in the placenta. Reduction of gravid uterine weight and the occurrence of abortion were observed in the 600 mg/kg/d TCS-exposed group. Moreover, hormone detection demonstrated that the serum levels of progesterone (P), estradiol (E2), testosterone (T), human chorionic gonadotropin (hCG) and prolactin (PRL) were decreased in groups exposed to higher doses of TCS. Real-time quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR) analysis revealed a significant increase in mRNA levels for placental steroid metabolism enzymes, including UDP-glucuronosyltransferase 1A1 (UGT1A1), estrogen sulfotransferase 1E1 (SULT1E1), steroid 5α-reductase 1 (SRD5A1) and steroid 5α-reductase 2 (SRD5A2). Furthermore, the transcriptional expression levels of progesterone receptor (PR), estrogen receptor (ERα) and androgen receptor (AR) were up-regulated. Taken together, these data demonstrated that the placenta was a target tissue of TCS and that TCS induced inhibition of circulating steroid hormone production might be related to the altered expression of hormone metabolism enzyme genes in the placenta. This hormone disruption might subsequently affect fetal development and growth.read more
Citations
More filters
Journal ArticleDOI
Triclosan exposure, transformation, and human health effects.
Lisa M. Weatherly,Julie A. Gosse +1 more
TL;DR: The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes, and the burgeoning literature on human health effects associated with T CS exposure, such as reproductive problems, was summarized.
Journal ArticleDOI
Exposure to endocrine disruptors during adulthood: consequences for female fertility
TL;DR: This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals on fertility during adult life and focuses on the hypothalamus, pituitary, ovary, and uterus to regulate normal female fertility and the onset of reproductive senescence.
Journal ArticleDOI
Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study.
Amira Aker,Lauren E. Johns,Thomas F. McElrath,David E. Cantonwine,Bhramar Mukherjee,John D. Meeker +5 more
TL;DR: Certain phenols and parabens were associated with altered thyroid hormone levels during pregnancy, and the timing of exposure influenced the association between phenol andParaben, and hormone concentrations.
Journal ArticleDOI
European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period.
Christian Vestergaard,Andreas Wollenberg,Sébastien Barbarot,Stéphanie Christen-Zaech,M. Deleuran,Phyllis I. Spuls,Carsten Flohr,Magdalena Trzeciak,L.B. von Kobyletzki,Julien Seneschal,Carle Paul,Thomas Bieber,Thomas Werfel,Regina Fölster-Holst,Ulf Darsow,Uwe Gieler,Åke Svensson,Michael J. Cork,J. F. Stalder,L. De Raeve,B. Kunz,Dagmar Simon,Pavel V Chernyshov,DirkJan Hijnen,Carlo Gelmetti,J. Ring,Alain Taieb,M S de Bruin-Weller,Jacob P. Thyssen +28 more
TL;DR: Treating future parents, as well as pregnant and lactating women with AD, the use of topical treatments including moisturizers, topical corticosteroids, tacrolimus, antiseptics andUltraviolet therapy may also be used.
Journal ArticleDOI
A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Amira Aker,Kelly K. Ferguson,Kelly K. Ferguson,Zaira Rosario,Bhramar Mukherjee,Akram N. Alshawabkeh,Antonia M. Calafat,José F. Cordero,John D. Meeker +8 more
TL;DR: Phenols and paraben are associated with hormone levels during pregnancy and there was evidence of susceptible windows of vulnerability for some associations.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance.
Dana W. Kolpin,Edward T. Furlong,Michael T. Meyer,E. Michael Thurman,Steven D. Zaugg,Larry B. Barber,Herbert T. Buxton +6 more
TL;DR: The U.S. Geological Survey used five newly developed analytical methods to measure concentrations of 95 organic wastewater contaminants (OWCs) in water samples from a network of 139 streams across 30 states during 1999 and 2000 as mentioned in this paper.
Journal ArticleDOI
Response to Comment on “Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance”
Dana W. Kolpin,Edward T. Furlong,Michael T. Meyer,E. Michael Thurman,Steven D. Zaugg,Larry B. Barber,Herbert T. Buxton +6 more
Journal ArticleDOI
Triclosan: Occurrence and fate of a widely used biocide in the aquatic environment: Field measurements in wastewater treatment plants, surface waters, and lake sediments
TL;DR: The measured vertical concentration profile of triclosan in a lake sediment core of lake Greifensee reflects its increased use over 30 years, and the measured concentrations in surface waters are in the range of the predicted no effect concentration of 50 ng/L.
Journal ArticleDOI
Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada.
TL;DR: Results of this study demonstrate that existing water treatment technologies can effectively remove certain PPCPs and other endocrine-disrupting chemicals in drinking water and sewage treatment processes.
Related Papers (5)
Triclosan: environmental exposure, toxicity and mechanisms of action
Andrea B. Dann,Alice Hontela +1 more