Endocytic uptake of nonenzymatically glycosylated proteins is mediated by a scavenger receptor for aldehyde-modified proteins.
TLDR
Endocytic uptake of AGE-proteins by macrophages appeared to be mediated by a scavenger receptor for aldehyde-modified proteins, providing evidence for the biological importance of the scavengers receptor in eliminating senescent macromolecules from the circulation.About:
This article is published in Journal of Biological Chemistry.The article was published on 1988-10-15 and is currently open access. It has received 161 citations till now. The article focuses on the topics: Scavenger receptor & Receptor.read more
Citations
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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
Journal ArticleDOI
Diabetes and advanced glycation endproducts.
Helen Vlassara,M.R. Palace +1 more
TL;DR: This data indicates that glycation endproducts are a viable source of disease progression in elderly people with diabetes and the use of these products should not be considered a substitute for medical treatment.
Journal ArticleDOI
AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept
TL;DR: AGEs elicit a wide range of cell-mediated responses that might contribute to the pathogenesis of diabetic complications, vascular and renal disease and Alzheimer's disease and Substances that inhibit AGE formation, reduce oxidative stress or destroy already formed crosslinks may limit the progression of disease.
Journal ArticleDOI
N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins.
TL;DR: It is concluded that AGEs are largely glycoxidation products and that CML is a major AGE recognized in tissue proteins by polyclonal antibodies to AGE proteins.
Journal ArticleDOI
Alterations in nonenzymatic biochemistry in uremia: Origin and significance of “carbonyl stress” in long-term uremic complications
Toshio Miyata,Toshio Miyata,Toshio Miyata,Charles van Ypersele de Strihou,Charles van Ypersele de Strihou,Charles van Ypersele de Strihou,Kiyoshi Kurokawa,Kiyoshi Kurokawa,Kiyoshi Kurokawa,John W. Baynes,John W. Baynes,John W. Baynes +11 more
TL;DR: Uremia may be described as a state of carbonyl overload or "carbonyl stress" resulting from either increased oxidation of carbohydrates and lipids (oxidative stress) or inadequate detoxification or inactivation of reactive carbonyL compounds derived from both carbohydrates andlipids by oxidative and nonoxidatives.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Measurement of protein using bicinchoninic acid
TL;DR: This new method maintains the high sensitivity and low protein-to-protein variation associated with the Lowry technique and demonstrates a greater tolerance of the bicinchoninate reagent toward such commonly encountered interferences as nonionic detergents and simple buffer salts.
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The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.
Pamela J. Fraker,John C. Speck +1 more
TL;DR: The stability and sparing solubility of this chloroglycoluril in water can account for the minimal damage to proteins and living cells observed in these iodinations and allow for elimination of the reduction step employed at the close of iodinations with soluble chloroamides such as chloramine-T.
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Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
TL;DR: The cholesteryl Ester/Protein Complexes from Atherosclerotic Plaques and the Foam Cell in Familial Hypercholesterolemia are studied.