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ENDOCYTOSIS: Concepts Emerging from the LDL Receptor System
Joseph L. Goldstein,Michael S. Brown,Richard G.W. Anderson,David W. Russell,Wolfgang J. Schne +4 more
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The article was published on 1985-01-01 and is currently open access. It has received 1265 citations till now. The article focuses on the topics: LDL receptor & Endocytosis.read more
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A receptor-mediated pathway for cholesterol homeostasis.
TL;DR: The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.
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The Caveolae Membrane System
TL;DR: Caveolae constitute an entire membrane system with multiple functions essential for the cell and are capable of importing molecules and delivering them to specific locations within the cell, exporting molecules to extracellular space, and compartmentalizing a variety of signaling activities.
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Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery
TL;DR: The different uptake pathways that are involved in nonviral gene delivery from a gene delivery point of view are reviewed and available knowledge concerning cellular entry and the intracellular trafficking of cationic lipid-DNA complexes (lipoplexes) and cationsic polymer- DNA complexes (polyplexes) is summarized.
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A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains.
TL;DR: This work proposes that the molecular address for proteins targeted to lipid domains is a lipid shell, which is high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling.
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Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
TL;DR: 79 additional mutations are described and the insights that all 150 mutations have provided into the structure/function relationship of the receptor protein and the clinical manifestations of FH are reviewed.
References
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Epidermal growth factor
TL;DR: The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
Axel Ullrich,Lisa M. Coussens,Joel S. Hayflick,Thomas J. Dull,Alane M. Gray,A W Tam,Jeffrey E. Lee,Yosef Yarden,Towia A. Libermann,Joseph Schlessinger +9 more
TL;DR: The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains.
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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Joseph L. Goldstein,M. S. Brown +1 more
TL;DR: The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.
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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Axel Ullrich,John Richard Bell,Ellson Y. Chen,R. Herrera,L. M. Petruzzelli,Thomas J. Dull,Alane M. Gray,Lisa M. Coussens,Yu Cheng Liao,M. Tsubokawa,Anthony J. Mason,Peter H. Seeburg,C. Grunfeld,Ora M. Rosen,J. Ramachandran,J. Ramachandran +15 more
TL;DR: The entire 1,370-amino-acid sequence of the human insulin receptor precursor is deduced from a single complementary DNA clone, finding sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
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Coated pits, coated vesicles, and receptor-mediated endocytosis
TL;DR: It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.