Endothelial Function, But Not Carotid Intima-Media Thickness, Is Affected Early in Menopause and Is Associated with Severity of Hot Flushes
Aris Bechlioulis,Sophia N. Kalantaridou,Katerina K. Naka,Anthoula Chatzikyriakidou,Karim A. Calis,Antonis Makrigiannakis,Odysseas Papanikolaou,Apostolos Kaponis,Christos S. Katsouras,Ioannis Georgiou,George P. Chrousos,Lampros K. Michalis +11 more
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TLDR
Impairment of endothelial function is present in the early menopausal years, whereas carotid IMT is not affected and the studied ER polymorphisms do not offer important information on vascular health in early menopause.Abstract:
Context: The effect of early menopause on indices of vascular function has been little studied. Objective: The objective of the study was to investigate the effect of early menopause on indices of subclinical atherosclerosis and identify predictors of those indices in early menopausal women. Design, Setting, and Participants: This was a cross-sectional study that included 120 early menopausal women (age range 42–55 yr, 0.8). Severity of hot flushes...read more
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The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society.
Charalambos Vlachopoulos,Panagiotis Xaplanteris,Victor Aboyans,Marianne Brodmann,Renata Cifkova,Francesco Cosentino,Marco De Carlo,Augusto Gallino,Ulf Landmesser,Stéphane Laurent,John Lekakis,Dimitri P. Mikhailidis,Katerina K. Naka,Athanasios Protogerou,Damiano Rizzoni,Arno Schmidt-Trucksäss,Luc M. Van Bortel,Thomas Weber,Akira Yamashina,Reuven Zimlichman,Pierre Boutouyrie,John R. Cockcroft,Michael F. O'Rourke,Jeong Bae Park,Giuseppe Schillaci,Henrik Sillesen,Raymond R. Townsend +26 more
TL;DR: The role of peripheral (i.e. not related to coronary circulation) noninvasive vascular biomarkers for primary and secondary cardiovascular disease prevention is scrutinized and it is still unclear whether a specific vascular biomarker is overly superior.
Journal ArticleDOI
Aging and vascular endothelial function in humans
TL;DR: Several lifestyle and biological factors modulate vascular endothelial function with aging, including regular aerobic exercise, dietary factors, vitamin D status, menopause/oestrogen deficiency and a number of conventional and non-conventional risk factors for CVD.
Journal ArticleDOI
Endothelial function is impaired across the stages of the menopause transition in healthy women
TL;DR: The findings suggest that a decline in endothelial function begins during the early stages of menopause (perimenopause) and worsens with the loss of ovarian function and prolonged estrogen deficiency, adding to the accumulating evidence that the perimenopausal window is a critical time period for adverse changes in CVD risk.
Journal ArticleDOI
Menopausal hot flushes and night sweats: Where are we now?
David F. Archer,David W. Sturdee,Rodney Baber,T. J. de Villiers,Amos Pines,Robert Freedman,Anne Gompel,Martha Hickey,Myra S. Hunter,Roger A. Lobo,Mary Ann Lumsden,Alastair H. MacLennan,Pauline M. Maki,Santiago Palacios,Duru Shah,P. Villaseca,Michelle P. Warren +16 more
TL;DR: Hot flushes are caused by changes in the central nervous system associated with estrogen withdrawal and are best treated with estrogen replacement therapy, and Objective monitoring of hot flushes indicates that placebo has little to no effect on their improvement.
Journal ArticleDOI
Vasomotor symptoms and cardiovascular events in postmenopausal women
Emily D. Szmuilowicz,JoAnn E. Manson,Jacques E. Rossouw,Barbara V. Howard,Karen L. Margolis,Nancy Greep,Robert G. Brzyski,Marcia L. Stefanick,Mary Jo O'Sullivan,Chunyuan Wu,Matthew A. Allison,Diederick E. Grobbee,Karen C. Johnson,Judith K. Ockene,Beatriz L. Rodriguez,Gloria E. Sarto,Mara Z. Vitolins,Ellen W. Seely,Ellen W. Seely +18 more
TL;DR: Early VMS were not associated with increased CVD risk, and were associated with decreased risk of stroke, total CVD events, and all-cause mortality.
References
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Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
Mary C. Corretti,Todd J. Anderson,Emelia J. Benjamin,David S. Celermajer,Francois Charbonneau,Mark A. Creager,John E. Deanfield,Helmut Drexler,Marie Gerhard-Herman,David M. Herrington,Patrick Vallance,Joseph A. Vita,Robert A. Vogel +12 more
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Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness A Systematic Review and Meta-Analysis
TL;DR: The relationship between IMT and risk was nonlinear, but the linear models fitted relatively well for moderate to high IMT values, and is a strong predictor of future vascular events.
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Role of Endothelial Dysfunction in Atherosclerosis
Jean Davignon,Peter Ganz +1 more
TL;DR: Clinical trials have shown that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) improve endothelial dysfunction in patients with coronary risk factors beyond what could be attributed to their impact on plasma lipids.
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Methodologic lessons learned from hot flash studies.
Jeff A. Sloan,Charles L. Loprinzi,Paul J. Novotny,Debra L. Barton,Beth I. LaVasseur,Harold E. Windschitl +5 more
TL;DR: Based on the data gained from a series of prospective clinical trials devoted to defining new treatment opportunities for hot flashes in cancer survivors, more efficient trials can be carried out to identify efficacious agents for the reduction of hot flash activity.
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High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from framingham to the veterans affairs high-density lipoprotein intervention trial
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